{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:25:54Z","timestamp":1777803954244,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,9,20]],"date-time":"2013-09-20T00:00:00Z","timestamp":1379635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>\n                    A boy with Pelizaeus-Merzbacher disease underwent repeated evaluations by 3-Tesla\n                    <jats:sup>1<\/jats:sup>\n                    H-magnetic resonance spectroscopy (MRS). The patient showed overlap of the PLP1. Individuals selected as normal controls for\n                    <jats:sup>1<\/jats:sup>\n                    H-magnetic resonance spectroscopy consisted of healthy age-matched children. For\n                    <jats:sup>1<\/jats:sup>\n                    H-magnetic resonance spectroscopy, the center of a voxel was positioned in the right parietal lobe.\n                    <jats:sup>1<\/jats:sup>\n                    H-magnetic resonance spectroscopy was performed when the patient was 2, 6, 14, and 25 months old. \u03b3-Aminobutyric acid concentration in early childhood was increased compared with that in normal controls. However, the \u03b3-aminobutyric acid concentration in the Pelizaeus-Merzbacher disease patient was normalized at 14 and 25 months. No remarkable changes were observed in choline-containing compounds concentration at any time. These results suggest that the changes in metabolite concentrations during growth can reflect the pathological condition of Pelizaeus-Merzbacher disease. Furthermore, the lack of change in the choline-containing compounds concentration can be useful for differentiating Pelizaeus-Merzbacher disease from other white matter disorders.\n                  <\/jats:p>","DOI":"10.1177\/0883073813499635","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:01:45Z","timestamp":1379721705000},"page":"283-288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-Related Changes in a Patient With Pelizaeus-Merzbacher Disease Determined by Repeated\n                    <sup>1<\/sup>\n                    H-Magnetic Resonance Spectroscopy"],"prefix":"10.1177","volume":"29","author":[{"given":"Tatsuo","family":"Mori","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan"},{"name":"Department of Nursing, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Goji","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahito","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Radiology, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kurosawa","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Kanagawa Children's Medical Center, Yokohama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kagami","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,20]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"150","volume-title":"Handbook of Clinical Neurology","author":"Seitelberger F","year":"1970","unstructured":"Seitelberger F. 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