{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:26:10Z","timestamp":1777803970520,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T00:00:00Z","timestamp":1380758400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:p>Development of both Crohn disease and Guillain-Barr\u00e9 syndrome likely involves autoimmunity associated with excessive inflammatory cytokines. We treated a girl who developed Guillain-Barr\u00e9 syndrome during the course of Crohn disease. Although high-dose \u03b3-globulin therapy administered initially for Guillain-Barr\u00e9 syndrome was ineffective, plasmapheresis ameliorated her acute neuropathic symptoms. Crohn disease was managed with Salazopyrin administration and enteral feeding. Chronic inflammation of the intestinal mucosa caused by Crohn disease can allow presentation of microbial intestinal antigens normally hidden from the immune system. Such presentation could incite an extraintestinal immune response on the basis of molecular mimicry, leading to activation of systemic autoimmunity against the nervous system. Accordingly, concurrence of Guillain-Barr\u00e9 syndrome and Crohn disease in our patient appeared to result from shared autoimmune mechanisms and systemic and local increases in cytokine concentrations. The patient also developed erythema nodosum and gall stones, relatively common complications of Crohn disease. However, Guillain-Barr\u00e9 syndrome is rare.<\/jats:p>","DOI":"10.1177\/0883073813503903","type":"journal-article","created":{"date-parts":[[2013,10,3]],"date-time":"2013-10-03T21:42:03Z","timestamp":1380836523000},"page":"NP78-NP80","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Guillain-Barr\u00e9 Syndrome and Crohn disease"],"prefix":"10.1177","volume":"29","author":[{"given":"Hidehiko","family":"Yanagida","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Kinki University Faculty of Medicine, Osaka-Sayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kinki University Faculty of Medicine, Osaka-Sayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akane","family":"Izu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kinki University Faculty of Medicine, Osaka-Sayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kinki University Faculty of Medicine, Osaka-Sayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kinki University Faculty of Medicine, Osaka-Sayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Kinki University Faculty of Medicine, Osaka-Sayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,10,3]]},"reference":[{"key":"bibr1-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60026-9"},{"key":"bibr2-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1110"},{"key":"bibr3-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30202-0"},{"key":"bibr4-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1718"},{"key":"bibr5-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1126\/science.1090124"},{"key":"bibr6-0883073813503903","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2012.00025"},{"key":"bibr7-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1159\/000186386"},{"key":"bibr8-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1080\/01971520009349543"},{"key":"bibr9-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2977(98)00147-8"},{"key":"bibr10-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1126\/science.1135245"},{"key":"bibr11-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.71.837.437"},{"key":"bibr12-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1007\/s001150050547"},{"key":"bibr13-0883073813503903","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.06.010"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073813503903","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073813503903","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073813503903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:38:21Z","timestamp":1777495101000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073813503903"}},"subtitle":["A Case Report"],"short-title":[],"issued":{"date-parts":[[2013,10,3]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1177\/0883073813503903"],"URL":"https:\/\/doi.org\/10.1177\/0883073813503903","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,3]]}}}