{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:43:21Z","timestamp":1780530201069,"version":"3.54.1"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>Cerebral sinovenous thrombosis is unusual during childhood and requires early and accurate management because of its detrimental consequences. We report on the case of a 2-year-old boy with mild psychomotor delay, who presented with nonfebrile acute ataxia. A brain computed tomographic (CT) scan showed complete thrombosis of the superior sagittal sinus, confirmed by magnetic resonance angiography and associated with a right frontal hemorrhagic infarction. Systematic screening for thrombophilia revealed homocystinuria linked to cystathionine \u03b2-synthase deficiency with underlying compound heterozygosity. The evolution was favorable after anticoagulant therapy, specific diet, and vitamin supplementation. This case is of interest because of the unusual clinical presentation as a pediatric cerebral sinovenous thrombosis. Furthermore, homocystinuria is rarely revealed by cerebral sinovenous thrombosis at the onset of the disease and should systematically be ruled out in pediatric stroke.<\/jats:p>","DOI":"10.1177\/0883073813520502","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T20:55:19Z","timestamp":1394052919000},"page":"107-112","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Inaugural Cerebral Sinovenous Thrombosis Revealing Homocystinuria in a 2-Year-Old Boy"],"prefix":"10.1177","volume":"30","author":[{"given":"C\u00e9cile","family":"Saboul","sequence":"first","affiliation":[{"name":"Department of Pediatrics, CHU Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Darteyre","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rehabilitation, CHU Saint-Etienne, Saint-Etienne, France"},{"name":"Research Group on Thrombosis\u2013EA 3065, Universit\u00e9 Jean Monnet, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Ged","sequence":"additional","affiliation":[{"name":"Department of Biology and Pathology, CHU Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Fichtner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rehabilitation, CHU Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gay","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Stephan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CHU Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"bibr1-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078894.79866.95"},{"key":"bibr2-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.8.763"},{"key":"bibr3-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1177\/088307389300800308"},{"key":"bibr4-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450604"},{"key":"bibr5-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1017\/S0012162299000250"},{"key":"bibr6-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2012.02.005"},{"key":"bibr7-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2000.00301.x"},{"key":"bibr8-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1177\/088307380101600913"},{"key":"bibr9-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2001000500032"},{"key":"bibr10-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1007\/BF02388172"},{"key":"bibr11-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000042479.55406.B3"},{"key":"bibr12-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.05.017"},{"key":"bibr13-0883073813520502","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1745.76110"},{"key":"bibr14-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0b013e31820a8364"},{"key":"bibr15-0883073813520502","first-page":"4939","volume":"32","author":"Smolle E","year":"2012","journal-title":"Anticancer Res"},{"key":"bibr16-0883073813520502","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2012.741731"},{"key":"bibr17-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20149"},{"key":"bibr18-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-830370"},{"key":"bibr19-0883073813520502","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2009.333"},{"key":"bibr20-0883073813520502","first-page":"2016","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Mudd SH","year":"2001","edition":"8"},{"key":"bibr21-0883073813520502","unstructured":"Yap S. 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