{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:18:56Z","timestamp":1777803536955,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    Autism spectrum disorders are neurodevelopmental disorders that are thought to be caused by a gene-by-environment interaction and in which various immune alterations are reported. We investigate CD4\n                    <jats:sup>+<\/jats:sup>\n                    T-cell cytokine profiles and subpopulations in 19-year-old monozygotic twins with autism and different comorbidities. CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from the twin with epilepsy produce more interferon-gamma, less interleukin-17, and have an increased interferon-\u03b3\/interleukin-4 ratio. CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells from the twin with multiple sclerosis exhibit a cytokine profile similar to an age and gender-matched control and a higher percentage of T regulatory (T\n                    <jats:sub>reg<\/jats:sub>\n                    ) cells. The twins\u2019 mother\u2019s T cells produce very high levels of both interleukin-17 and interferon-\u03b3. Cytokine and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T-cell abnormalities in the twins could contribute to or be a result of the manifestation of their divergent comorbidities. A proinflammatory, autoimmune-polarized cytokine profile is observed in this unique family with autism.\n                  <\/jats:p>","DOI":"10.1177\/0883073814529821","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T01:25:06Z","timestamp":1397611506000},"page":"386-390","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report"],"prefix":"10.1177","volume":"30","author":[{"given":"Jessica","family":"Magid-Bernstein","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosciences, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kedar","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Thomas Jefferson University Hospitals, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Lincoln","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Medical School, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosciences, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Rohowsky-Kochan","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosciences, Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, NJ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"bibr1-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1989.tb00254.x"},{"key":"bibr2-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1007\/BF01537954"},{"key":"bibr3-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1177\/088307389901400608"},{"key":"bibr4-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2445"},{"key":"bibr5-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.07.004"},{"key":"bibr6-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1381.010"},{"key":"bibr7-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(97)00045-3"},{"key":"bibr8-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.08.005"},{"key":"bibr9-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(96)00014-8"},{"key":"bibr10-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(98)00021-6"},{"key":"bibr11-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2005.11.007"},{"key":"bibr12-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1177\/0883073809339393"},{"key":"bibr13-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.9.1691"},{"key":"bibr14-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2012.04654.x"},{"key":"bibr15-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033224"},{"key":"bibr16-0883073814529821","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05133.x"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073814529821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073814529821","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073814529821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:36:43Z","timestamp":1777495003000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073814529821"}},"subtitle":["Cytokine and CD4\n                    <sup>+<\/sup>\n                    T-Cell Profiles of Monozygotic Twins With Autism and Divergent Comorbidities and Drug Treatment"],"short-title":[],"issued":{"date-parts":[[2014,4,15]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1177\/0883073814529821"],"URL":"https:\/\/doi.org\/10.1177\/0883073814529821","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,15]]}}}