{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:19:13Z","timestamp":1777803553300,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Mechanism of seizure refractoriness to antiepileptic drugs in children with Lennox-Gastaut syndrome is not known. Efflux of antiepileptic drugs due to increased expression\/function of P-glycoprotein, a multidrug efflux transporter protein on the cell surface is a proposed mechanism. The authors studied the expression\/function of P-glycoprotein on peripheral blood mononuclear cells of 29 children with Lennox-Gastaut syndrome, 23 children with other epilepsies, and 19 healthy children. The authors found a higher P-glycoprotein expression\/function in Lennox-Gastaut syndrome, a higher percent positive cells as compared to children with other epilepsy ( P &lt; 0.001) and to healthy controls ( P = 0.012), higher P-glycoprotein expression as compared to healthy controls ( P = 0.003), a higher total P-glycoprotein expression (relative florescence intensity \u00d7 percent positive cells) as compared to children with other epilepsies ( P &lt; 0.001) and healthy controls ( P &lt; 0.001), and a higher P-glycoprotein function as compared to children with other epilepsies ( P = 0.001) and healthy controls ( P = 0.002). These findings may explain seizure refractoriness to anti-epileptic drugs in Lennox-Gastaut syndome.<\/jats:p>","DOI":"10.1177\/0883073814532545","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T21:08:20Z","timestamp":1398373700000},"page":"223-227","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Role of P-Glycoprotein in Refractoriness of Seizures to Antiepileptic Drugs in Lennox-Gastaut Syndrome"],"prefix":"10.1177","volume":"30","author":[{"given":"Achal","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Neurology, SGPGIMS, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deepak","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, SGPGIMS, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vimal Kumar","family":"Paliwal","sequence":"additional","affiliation":[{"name":"Department of Neurology, SGPGIMS, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafar","family":"Neyaz","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, SGPGIMS, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, SGPGIMS, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"bibr1-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2005.11.014"},{"key":"bibr2-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05316.x"},{"key":"bibr3-0883073814532545","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1542\/peds.5.4.626","volume":"5","author":"Lennox WG","year":"1950","journal-title":"Pediatrics"},{"key":"bibr4-0883073814532545","first-page":"125","volume-title":"Epileptic syndromes in infancy, childhood and adolescence","author":"Beaumanoir A","year":"2005"},{"key":"bibr5-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70292-8"},{"key":"bibr6-0883073814532545","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.eplepsyres.2004.06.004","volume":"60","author":"Loscher W","year":"2004","journal-title":"Epilepsy Res"},{"key":"bibr7-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.1.7"},{"key":"bibr8-0883073814532545","doi-asserted-by":"publisher","DOI":"10.2174\/1389450033490894"},{"key":"bibr9-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2001.12301.x"},{"key":"bibr10-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1007\/s002800051053"},{"key":"bibr11-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03573-X"},{"key":"bibr12-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf002"},{"key":"bibr13-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00992-2"},{"key":"bibr14-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1995.tb01657.x"},{"key":"bibr15-0883073814532545","doi-asserted-by":"publisher","DOI":"10.4103\/0972-2327.53076"},{"key":"bibr16-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2003.42802.x"},{"key":"bibr17-0883073814532545","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200402000-00010"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073814532545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073814532545","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073814532545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:36:48Z","timestamp":1777495008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073814532545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,23]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1177\/0883073814532545"],"URL":"https:\/\/doi.org\/10.1177\/0883073814532545","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,23]]}}}