{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:25:43Z","timestamp":1792794343649,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T00:00:00Z","timestamp":1400025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>To investigate clinical correlates of Tourette syndrome and to identify the impact of comorbidities, we retrospectively recruited 92 young people affected by Tourette syndrome compared with 102 healthy controls. Neuropsychological assessment included: Youth Quality of Life\u2013Research, Multidimensional Anxiety Scale for Children, Children\u2019s Depression Inventory, and Conner\u2019s and Child Behavior Checklist; moreover, Tourette syndrome patients completed the Yale Global Tic Severity Rating Scale and the Yale-Brown Obsessive Compulsive Scale. Four clinical subgroups were identified: pure Tourette syndrome (49.8%), Tourette syndrome plus attention-deficit hyperactivity disorder (ADHD) (22.2%), Tourette syndrome plus obsessive-compulsive disorder (21.5%), and Tourette syndrome plus ADHD plus obsessive-compulsive disorder (6.5%). Our findings suggested that emotional lability appeared in all Tourette syndrome subgroups, independently from comorbidities, representing a clinical feature of Tourette syndrome itself. Moreover, our data suggested that all 4 clinical subgroups had higher statistically significant behavioral problems compared with the healthy controls ( P = .000), whereas affective and anxiety symptoms were overrepresented in Tourette syndrome plus comorbidities subgroups. Finally, Tourette syndrome patients had a lower quality of life compared with the healthy controls. These differences were statistically significant between the pure Tourette syndrome subgroups and Tourette syndrome plus comorbidities subgroups, as well as Tourette syndrome plus comorbidities subgroups and healthy controls.<\/jats:p>","DOI":"10.1177\/0883073814534317","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T21:19:27Z","timestamp":1400188767000},"page":"1383-1389","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":50,"title":["Tourette Syndrome and Comorbid Conditions"],"prefix":"10.1177","volume":"29","author":[{"given":"Renata","family":"Rizzo","sequence":"first","affiliation":[{"name":"Section of Child Neuropsychiatry, Dipartimento di Scienze Mediche e Pediatriche, Catania University, Via Santa Sofia, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Gulisano","sequence":"additional","affiliation":[{"name":"Section of Child Neuropsychiatry, Dipartimento di Scienze Mediche e Pediatriche, Catania University, Via Santa Sofia, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pellico","sequence":"additional","affiliation":[{"name":"Section of Child Neuropsychiatry, Dipartimento di Scienze Mediche e Pediatriche, Catania University, Via Santa Sofia, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola Valeria","family":"Cal\u00ec","sequence":"additional","affiliation":[{"name":"Section of Child Neuropsychiatry, Dipartimento di Scienze Mediche e Pediatriche, Catania University, Via Santa Sofia, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Curatolo","sequence":"additional","affiliation":[{"name":"Section of Child Neuropsychiatry, Department of Neurosciences, University Tor Vergata, Via Montpellier, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,14]]},"reference":[{"key":"bibr1-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.01.016"},{"key":"bibr2-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2008.03.006"},{"key":"bibr3-0883073814534317","first-page":"94","volume":"15","author":"Steinberg T","year":"2013","journal-title":"Isr Med Assoc J"},{"key":"bibr4-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2009.09.002"},{"key":"bibr5-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.11.006"},{"key":"bibr6-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.03.010"},{"key":"bibr7-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300585"},{"key":"bibr8-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22900"},{"key":"bibr9-0883073814534317","first-page":"821","volume":"109","author":"Ludolph AG","year":"2012","journal-title":"Dtsch Arztebl Int"},{"key":"bibr10-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.12.003"},{"key":"bibr11-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5754-6"},{"key":"bibr12-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.151"},{"key":"bibr13-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2012.00778.x"},{"key":"bibr14-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq293"},{"key":"bibr15-0883073814534317","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1234-988X(199612)6:4<203::AID-MPR165>3.3.CO;2-F"},{"key":"bibr16-0883073814534317","volume-title":"Wechsler Intelligence Scale for Children\u2014Third Edition","author":"Wechsler D","year":"1991"},{"key":"bibr17-0883073814534317","unstructured":"Topolski TD, Edwards TC, Patrick DL. 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