{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:20:08Z","timestamp":1777803608627,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,6,22]],"date-time":"2014-06-22T00:00:00Z","timestamp":1403395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>The aim of this study was to investigate the effects of valproate and carbamazepine, on renal glomerular and tubular functions. The patient group comprised 54 children with new-onset epilepsy treated with valproate (n = 30) and carbamazepine (n = 24). Twenty-six healthy children were in the control group. The serum creatinine and cystatin C levels and urinary excretion of N-acetyl-\u03b2-d-glucosaminidase (NAG) levels were measured and the glomerular filtration rate (GFR) was estimated. Serum creatinine and cystatin C concentrations were not different between patients and controls. The glomerular filtration rate of the patient groups were higher than those of the control group. Thus, both drugs probably lead to glomerular hyperfiltration and toxicity for glomerular functions. However, urinary N-acetyl-\u03b2-d-glucosaminidase\/creatinine levels were significantly higher in patients receiving only valproate (6.1 \u00b1 5). The difference between carbamazepine and control groups was not significant for urinary N-acetyl-\u03b2-d-glucosaminidase\/creatinine levels. Our data suggest that valproate has adverse effects on renal tubular functions.<\/jats:p>","DOI":"10.1177\/0883073814538505","type":"journal-article","created":{"date-parts":[[2014,6,23]],"date-time":"2014-06-23T20:31:53Z","timestamp":1403555513000},"page":"301-306","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Does Nephrotoxicity Exist in Pediatric Epileptic Patients on Valproate or Carbamazepine Therapy?"],"prefix":"10.1177","volume":"30","author":[{"given":"Cengiz","family":"Havali","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u0131v\u0131lc\u0131m","family":"G\u00fcc\u00fcyener","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Necla","family":"Buyan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Nephrology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcnsal","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Dr. Beh\u00e7et Uz Children's Hospital, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"G\u00fcrka\u015f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6zlem","family":"G\u00fclbahar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ercan","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Serdaro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Gazi University Faculty of Medicine, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,6,22]]},"reference":[{"key":"bibr1-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1177\/08830738020170010201"},{"key":"bibr2-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1177\/088307380401900406"},{"issue":"3","key":"bibr3-0883073814538505","first-page":"CD001030","author":"Marson AG","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr4-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2006.00699.x"},{"key":"bibr5-0883073814538505","first-page":"75","volume":"48","author":"Sk\u00e1lov\u00e1 S","year":"2005","journal-title":"Acta Medica"},{"key":"bibr6-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1016\/0387-7604(93)90055-D"},{"key":"bibr7-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1159\/000242679"},{"key":"bibr8-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1136\/adc.83.5.420"},{"key":"bibr9-0883073814538505","unstructured":"Biomarkers for the early detection of acute kidney injury. Pediatric Nephrology Educational Feature Nephrology and Hypertension, MLC 7022, Cincinnati Children\u2019s Hospital Medical Center."},{"key":"bibr10-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.02.004"},{"key":"bibr11-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2006.10.014"},{"key":"bibr12-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36251-4"},{"key":"bibr13-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.04.085"},{"key":"bibr14-0883073814538505","first-page":"1306","volume-title":"Pediatric Nephrology","author":"Holliday MA","year":"1994","edition":"3"},{"key":"bibr15-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1007\/BF00852829"},{"key":"bibr16-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(98)00079-4"},{"key":"bibr17-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.2000.tb00118.x"},{"key":"bibr18-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1994.tb18133.x"},{"key":"bibr19-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/43.6.913"},{"key":"bibr20-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03152-4"},{"key":"bibr21-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/40.10.1921"},{"key":"bibr22-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/44.7.1535"},{"key":"bibr23-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-013-2426-7"},{"key":"bibr24-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1991.277"},{"key":"bibr25-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.127"},{"key":"bibr26-0883073814538505","doi-asserted-by":"publisher","DOI":"10.5581\/1516-8484.20130107"},{"key":"bibr27-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460070070045"},{"key":"bibr28-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1993.57"},{"key":"bibr29-0883073814538505","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1681\/ASN.V291417","volume":"2","author":"Hirschberg R","year":"1992","journal-title":"J Am Soc Nephrol"},{"key":"bibr30-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1016\/1056-8727(95)80028-D"},{"key":"bibr31-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2005.01497.x"},{"key":"bibr32-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00588.x"},{"key":"bibr33-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00806.x"},{"key":"bibr34-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.301"},{"key":"bibr35-0883073814538505","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000535"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073814538505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073814538505","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073814538505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:37:05Z","timestamp":1777495025000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073814538505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,22]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1177\/0883073814538505"],"URL":"https:\/\/doi.org\/10.1177\/0883073814538505","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,22]]}}}