{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:56:38Z","timestamp":1788454598056,"version":"build-2803163510"},"reference-count":9,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T00:00:00Z","timestamp":1426032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>The large randomized, controlled trials of therapeutic hypothermia for hypoxic-ischemic encephalopathy excluded neonates with congenital disorders. The objective of this study was to report our experience using hypothermia in neonates with signs of hypoxic-ischemic encephalopathy and a syndromic disorder or brain anomaly. Subjects were identified from a database of neonates admitted to the Neuro-Intensive Care Nursery at University of California, San Francisco. Of 169 patients fulfilling criteria for hypothermia, 8 (5%) had a syndromic disorder and were cooled per guidelines for nonsyndromic neonates. Perinatal characteristics of infants with and without syndromic disorder were not significantly different. Overall outcome was poor: 38% had evidence of acute hypoxic-ischemic injury, 3 subjects died, and 2 survivors had low developmental quotient (ie, 25). The risk versus benefit of therapeutic hypothermia for hypoxic-ischemic encephalopathy among neonates with congenital brain malformations or syndromic diagnoses is uncertain.<\/jats:p>","DOI":"10.1177\/0883073815569307","type":"journal-article","created":{"date-parts":[[2015,3,11]],"date-time":"2015-03-11T21:13:59Z","timestamp":1426108439000},"page":"1453-1458","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcome After Therapeutic Hypothermia in Term Neonates With Encephalopathy and a Syndromic Diagnosis"],"prefix":"10.1177","volume":"30","author":[{"given":"Anna","family":"Mrelashvili","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia L.","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Shimotake","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C.","family":"Glass","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California, San Francisco, CA, USA"},{"name":"Department of Neurology, University of California, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,3,11]]},"reference":[{"key":"bibr1-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-3995-2.10009-3"},{"key":"bibr2-0883073815569307","first-page":"CD003311","volume":"1","author":"Jacobs SE","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"bibr3-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-17"},{"key":"bibr4-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"bibr5-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7172.1549"},{"key":"bibr6-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182a265ab"},{"key":"bibr7-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12017"},{"key":"bibr8-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0714"},{"key":"bibr9-0883073815569307","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2000.tb00693.x"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073815569307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073815569307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073815569307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:37:49Z","timestamp":1777495069000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073815569307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,11]]},"references-count":9,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1177\/0883073815569307"],"URL":"https:\/\/doi.org\/10.1177\/0883073815569307","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,11]]}}}