{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:20:39Z","timestamp":1793409639843,"version":"4.5.0"},"reference-count":65,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T00:00:00Z","timestamp":1430956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:p>\n                    We studied 27 infants aged 6 to 27 months with vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency also known as \u201cinfantile tremor syndrome\u201d in India. All were exclusively breast-fed by vegetarian mothers. Developmental delay or regression, pallor, skin hyperpigmentation, and sparse brown hair were present in all. Majority were hypotonic and involuntary movements were encountered in 18. Anemia and macrocytosis was found in 83% and 71% infants, respectively. Low serum vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    was present in 12 of 21 infants. Seven of the 9 infants with normal serum vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    had received vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    before referral. Twelve mothers had low serum vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    . Cerebral atrophy was present in all the 9 infants who underwent neuroimaging. Treatment with vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    resulted in dramatic improvement in general activity and appetite within 48 to 72 hours followed by return of lost milestones. Tremors resolved in all by 3 to 4 weeks. Nutritional vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency is a treatable cause of neurologic dysfunction in infants.\n                  <\/jats:p>","DOI":"10.1177\/0883073815583688","type":"journal-article","created":{"date-parts":[[2015,5,7]],"date-time":"2015-05-07T22:02:35Z","timestamp":1431036155000},"page":"1831-1837","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":66,"title":["Neurology of Nutritional Vitamin B\n                    <sub>12<\/sub>\n                    Deficiency in Infants"],"prefix":"10.1177","volume":"30","author":[{"given":"Jatinder Singh","family":"Goraya","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"},{"name":"Department of Pediatrics, Dayanand Medical College and Hospital, Ludhiana, Punjab, 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