{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:13:23Z","timestamp":1791357203092,"version":"4.3.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:p>\n                    This retrospective study aimed to compare the therapeutic response, including side effects, for oral baclofen versus oral tizanidine therapy with adjuvant botulinum toxin type A in a group of 64 pediatric patients diagnosed with static encephalopathy and spastic equinus foot deformity. Following botulinum toxin A treatment, clinical improvement led to the gradual reduction of baclofen or tizanidine dosing to one-third of the former dose. Gross Motor Functional Measure and Caregiver Health Questionnaire scores were markedly elevated post\u2013botulinum toxin A treatment, with scores for the tizanidine (Gross Motor Functional Measure: 74.45 \u00b1 3.72; Caregiver Health Questionnaire: 72.43 \u00b1 4.29) group significantly higher than for the baclofen group (Gross Motor Functional Measure: 68.23 \u00b1 2.66; Caregiver Health Questionnaire: 67.53 \u00b1 2.67,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001). These findings suggest that the combined use of botulinum toxin A and a low dose of tizanidine in treating children with cerebral palsy appears to be more effective and has fewer side effects versus baclofen with adjuvant botulinum toxin A.\n                  <\/jats:p>","DOI":"10.1177\/0883073815587030","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T21:35:39Z","timestamp":1432244139000},"page":"184-189","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity"],"prefix":"10.1177","volume":"31","author":[{"given":"Alper I.","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, Division of Pediatric Neurology, University of Gaziantep, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sefika N.","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah T.","family":"Demiry\u00fcrek","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.tb12627.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12080"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70176-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3944\/AOTT.2009.081"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cbcd2f"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PEP.0000096381.10102.FA"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(03)00269-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/7010.2006.00225"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00818.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-2000-00137"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016470310018315"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/BPB.0b013e328092562b"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20088"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.5.1062"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2310\/7010.2006.00041"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(11)60033-8"},{"key":"e_1_3_3_18_2","first-page":"E355","article-title":"Chirality counts?","volume":"15","author":"Smith HS","year":"2012","unstructured":"Smith HS. 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