{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:06:42Z","timestamp":1781647602905,"version":"3.54.5"},"reference-count":32,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>PHACE ( posterior fossa brain malformation, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities) syndrome is a neurocutaneous disorder often involving the cerebral vasculature. PHACE patients appear to have early-onset and severe headaches more commonly than children without PHACE. The objective of this study was to characterize the clinical features and prevalence of headache by conducting a cross-sectional survey of families in 2 large PHACE registries. Sixty-six percent of eligible families completed the survey in which 62.7% of respondents reported headaches. Average age of headache onset was 48.8 months. Females were more likely to have headaches (68.6% vs 30.8%, P = .014). Families reported associated migrainous features including nausea (62.5%), vomiting (37.5%), photophobia (75%), and phonophobia (75%). Headaches occurred at least weekly in 29.4%, lasted \u22651 hour in 85.4%, and led to \u22651 hospital admission in 15.7%. Three respondents with headaches had at least 1 ischemic stroke. We demonstrated that headaches are common among PHACE patients, develop at an early age, and have migrainous features.<\/jats:p>","DOI":"10.1177\/0883073815599261","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T22:09:44Z","timestamp":1439503784000},"page":"468-473","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence and Clinical Characteristics of Headaches in PHACE Syndrome"],"prefix":"10.1177","volume":"31","author":[{"given":"JiaDe","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn H.","family":"Siegel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A.","family":"Drolet","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Blei","sequence":"additional","affiliation":[{"name":"Vascular Anomalies Program, Lenox Hill Hospital, Northshore-LIJ Healthcare System, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon G.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Metry","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Texas Children\u2019s Hospital, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey L.","family":"Heyer","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology, Division of Pediatric Neurology, Nationwide Children\u2019s Hospital and The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"bibr1-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0082"},{"key":"bibr2-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890270083012"},{"key":"bibr3-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31189"},{"key":"bibr4-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.114880"},{"key":"bibr5-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12304"},{"key":"bibr6-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812450073"},{"key":"bibr7-0883073815599261","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2206"},{"key":"bibr8-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-1008"},{"key":"bibr9-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1177\/0333102413485658"},{"key":"bibr10-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.11.2034"},{"key":"bibr11-0883073815599261","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1976.hed1504288.x"},{"key":"bibr12-0883073815599261","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1542\/peds.79.5.677","volume":"79","author":"Zuckerman B","year":"1987","journal-title":"Pediatrics"},{"key":"bibr13-0883073815599261","first-page":"1","volume":"136","author":"Bille BS. 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