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The purpose of the current study was to identify topographical patterns in the distribution specific to epileptogenic (n = 37) and nonepileptogenic (n = 544) tubers throughout the brain for a cohort of 23 tuberous sclerosis complex patients with a history of seizures. Tubers localized to the inferior parietal lobes, middle frontal lobes, middle temporal lobes, or central sulcus regions were associated with a high frequency of epileptogenic tubers. Epileptogenic tubers occurred statistically more frequently within the inferior parietal lobe and within the central sulcus region in children younger than 1 or between 1 and 3 years old, respectively. Results imply seizure activity in tuberous sclerosis complex patients can be associated with the location of cortical tubers.<\/jats:p>","DOI":"10.1177\/0883073815609151","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T22:19:27Z","timestamp":1444947567000},"page":"636-645","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Topographical Distribution of Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex"],"prefix":"10.1177","volume":"31","author":[{"given":"Benjamin M.","family":"Ellingson","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA"},{"name":"Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, 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