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Delayed synaptic maturation may explain neurogenic apnea or hypoventilation of prematurity and some cases of sudden infant death syndrome. Sections of medulla oblongata were studied from 30 human fetal and neonatal brains 9 to 41 weeks\u2019 gestation. Synaptophysin demonstrated the immunocytochemical sequence of synaptogenesis. Other neuronal markers and myelin stain also were applied. The nucleus\/tractus solitarius was similarly studied in fetuses with chromosomopathies, metabolic encephalopathies, and brain malformations. Synapse formation in the nucleus solitarius begins at about 12 weeks\u2019 gestation and matures by 15 weeks; myelination initiated at 33 weeks. Synaptogenesis was delayed in 3 fetuses with different conditions, but was not specific for only nucleus solitarius. Delayed synaptogenesis or myelination in the nucleus solitarius may play a role in neonatal hypoventilation, especially in preterm infants and in some sudden infant death syndrome cases.<\/jats:p>","DOI":"10.1177\/0883073815615227","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T21:38:45Z","timestamp":1449783525000},"page":"722-732","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Synaptogenesis and Myelination in the Nucleus\/Tractus Solitarius"],"prefix":"10.1177","volume":"31","author":[{"given":"Harvey B.","family":"Sarnat","sequence":"first","affiliation":[{"name":"Departments of Paediatrics, Pathology (Neuropathology) and Clinical Neurosciences, University of Calgary and Alberta Children\u2019s Hospital Research Institute, Calgary Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Flores-Sarnat","sequence":"additional","affiliation":[{"name":"Departments of Paediatrics, Pathology (Neuropathology) and Clinical Neurosciences, University of Calgary and Alberta Children\u2019s Hospital Research Institute, Calgary Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"bibr1-0883073815615227","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00144.2014"},{"key":"bibr2-0883073815615227","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1910"},{"key":"bibr3-0883073815615227","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20527"},{"key":"bibr4-0883073815615227","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1441-0"},{"key":"bibr5-0883073815615227","volume-title":"Cytoarchitecture of the Human Brain Stem","author":"Olszewski J","year":"1954"},{"key":"bibr6-0883073815615227","unstructured":"Crosby EC, Humphrey T, Lauer EW. 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