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This study quantified lower leg bone, muscle, and adipose tissue volume in children with myelomeningocele, classifying adipose as subcutaneous or muscle-associated. Eighty-eight children with myelomeningocele and 113 children without myelomeningocele underwent lower leg computed tomographic scans. Subcutaneous and muscle-associated adipose were classified based on location relative to the crural fascia. No differences were seen in subcutaneous adipose. Higher level disease severity was associated with increased muscle-associated adipose volume and decreased muscle volume. Bone volume tended to decrease with higher levels of involvement. Increases in lower leg adiposity in children with myelomeningocele are primarily attributable to accumulation of muscle-associated adipose, which may signify increased risk for metabolic disorders.<\/jats:p>","DOI":"10.1177\/0883073816634858","type":"journal-article","created":{"date-parts":[[2016,3,9]],"date-time":"2016-03-09T21:44:41Z","timestamp":1457559881000},"page":"979-984","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Quantitative Analysis of Lower Leg Adipose Tissue Distribution in Youth with Myelomeningocele"],"prefix":"10.1177","volume":"31","author":[{"given":"Daniel J.","family":"Lorenzana","sequence":"first","affiliation":[{"name":"Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole M.","family":"Mueske","sequence":"additional","affiliation":[{"name":"Children\u2019s Orthopaedic Center, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deirdre D.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"},{"name":"Children\u2019s Orthopaedic Center, Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander L.","family":"Van Speybroeck","sequence":"additional","affiliation":[{"name":"Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tishya A. 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