{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:56:48Z","timestamp":1792166208726,"version":"4.4.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>Intrathecal baclofen therapy is widely accepted as a treatment option for patients with severe spasticity. The current treatment of spasticity in patients with Sj\u00f6gren-Larsson syndrome is largely symptomatic, given that no effective causal therapy treatments are available. We report the outcome of 2 patients with Sj\u00f6gren-Larsson syndrome who had pump implantation for intrathecal baclofen. We observed a positive response, with a decrease of spasticity, reflecting in the Modified Ashworth Scale, and parents and caregivers observed a functional improvement in both patients. One patient experienced skin irritation 15 months after surgery, necessitating pump repositioning. No infection occurred. Our report shows that intrathecal baclofen therapy can have a positive therapeutic effect on spasticity in patients with Sj\u00f6gren-Larsson syndrome, and therefore may be a promising addition to current treatments.<\/jats:p>","DOI":"10.1177\/0883073816671440","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T21:10:38Z","timestamp":1475788238000},"page":"100-103","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Intrathecal Baclofen Therapy for the Treatment of Spasticity in Sj\u00f6gren-Larsson Syndrome"],"prefix":"10.1177","volume":"32","author":[{"given":"Eveline Teresa","family":"Hidalgo","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery, Department of Neurosurgery, NYU Langone Medical Center, NY, 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