{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:46:22Z","timestamp":1790419582441,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:p>We retrospectively reviewed the clinical and radiologic characteristics of 17 individuals with septo-optic dysplasia (SOD) and attempted to identify correlations between imaging findings, clinical features, and neurodevelopmental outcome. Surprisingly, only 1 (6%) individual was classified as classic SOD (with septum pellucidum\/corpus callosum dysgenesis), 3 (18%) as SOD-like (with normal septum pellucidum\/corpus callosum) and the majority, 13 (76%), as SOD-plus (with cortical brain malformation). Cortical abnormalities included schizencephaly, polymicrogyria, and gray matter heterotopias. All individuals had optic nerve hypoplasia, 11 (65%) had endocrinologic deficits, and 13 (76%) had abnormal cerebral midlines. Seven individuals (41%) had all 3 features. Neurodevelopmental outcome was abnormal in 13 (78%), ranging from mild to severe developmental delay. Individuals with SOD-plus did not have more severe neurologic deficits than individuals with classic or SOD-like subgroups. Thus, SOD is clinically and radiologically heterogeneous, and cortical abnormalities are very common. Neurodevelopmental deficits are very prevalent, and of wide-ranging severity.<\/jats:p>","DOI":"10.1177\/0883073817707300","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T01:22:06Z","timestamp":1494292926000},"page":"797-803","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Clinical and Radiologic Spectrum of Septo-optic Dysplasia: Review of 17 Cases"],"prefix":"10.1177","volume":"32","author":[{"given":"Callie","family":"Alt","sequence":"first","affiliation":[{"name":"McGill University, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Shevell","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Neurology, and Neurosurgery, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Poulin","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Neurology, and Neurosurgery, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Rosenblatt","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Neurology, and Neurosurgery, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Saint-Martin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Montreal Children\u2019s Hospital, McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Srour","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, Neurology, and Neurosurgery, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,5,8]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"267","article-title":"Studies on malformation of cranio-encephalic sutures. 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