{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:59:17Z","timestamp":1793447957291,"version":"4.5.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>The association of infantile spasms and periventricular leukomalacia and\/or intraventricular hemorrhage is well documented. Data regarding early treatment-based and long-term outcomes are limited. A retrospective chart review identified children with infantile spasms born prematurely (&lt;37 weeks) with diagnoses of periventricular leukomalacia and\/or intraventricular hemorrhage. Thirteen children were included. Median gestational age was 30 weeks and age of onset of infantile spasms was 8 months. Nine children had intraventricular hemorrhage, 10 had periventricular leukomalacia, and 6 children had both. Twelve of 13 children had resolution of spasms. In responders, the successful medication was adrenocorticotropic hormone (ACTH) in 7, topiramate in 3, and vigabatrin in 2. Follow-up after a median of 7.1 years found that all patients had developmental delay but only 1 had refractory epilepsy. Standard therapies (ACTH and vigabatrin) appeared to be more effective than other treatments. Developmental delay is common in children with periventricular leukomalacia \/ intraventricular hemorrhage and infantile spasms, but refractory epilepsy might be less frequent.<\/jats:p>","DOI":"10.1177\/0883073817712587","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T06:36:48Z","timestamp":1498027008000},"page":"861-866","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Infantile Spasms and Injuries of Prematurity: Short-Term Treatment-Based Response and Long-Term Outcomes"],"prefix":"10.1177","volume":"32","author":[{"given":"Adam","family":"Wallace","sequence":"first","affiliation":[{"name":"Department of Neurology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Allen","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, University of Colorado, Children\u2019s Hospital Colorado, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neurology, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Knupp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Neurology, University of Colorado School of Medicine, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2017,6,21]]},"reference":[{"key":"bibr1-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02522.x"},{"key":"bibr2-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12951"},{"key":"bibr3-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1996.tb15027.x"},{"key":"bibr4-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(87)80113-4"},{"key":"bibr5-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02695.x"},{"key":"bibr6-0883073817712587","first-page":"1362","volume":"25","author":"Caraballo R","year":"1997","journal-title":"Rev Neurol"},{"key":"bibr7-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2012.03708.x"},{"key":"bibr8-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1993.tb00455.x"},{"key":"bibr9-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00323-8"},{"key":"bibr10-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24594"},{"key":"bibr11-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318259e2cf"},{"key":"bibr12-0883073817712587","volume":"6","author":"Hancock E","year":"2013","journal-title":"Cochrane Library"},{"key":"bibr13-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03127.x"},{"key":"bibr14-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1542\/peds.89.1.91"},{"issue":"1","key":"bibr15-0883073817712587","first-page":"105","volume":"32","author":"Kuzmani\u0107-Samija R","year":"2008","journal-title":"Coll Antropol"},{"key":"bibr16-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb00773.x"},{"key":"bibr17-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200311000-00004"},{"key":"bibr18-0883073817712587","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.11.012"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073817712587","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073817712587","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073817712587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:39:10Z","timestamp":1777495150000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073817712587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,21]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1177\/0883073817712587"],"URL":"https:\/\/doi.org\/10.1177\/0883073817712587","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,21]]}}}