{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:30:20Z","timestamp":1777804220767,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Isolated optic nerve glioma is a rare tumor with no consensus for the best therapeutic approach. Therefore, tumor control and preservation of visual function remain a challenge. In this retrospective study, we describe our experience over 30 years in a single-institutional cohort of children with isolated optic nerve glioma, focusing on treatments and visual outcomes. Seventeen children were followed for a median period of 8 years (range, 2-22 years). Diagnosis was based on typical neuroradiologic findings, and 3 patients had histologic confirmation of their tumors. In our study, conservative management preserved the vision of most patients with neurofibromatosis type 1 (NF1). NF1-related optic nerve gliomas were less often treated but were associated with a lower probability of progression and with occasional spontaneous regression. Sporadic tumors more frequently exhibited aggressive clinical behavior with a higher propensity for posterior extension, often requiring surgical intervention.<\/jats:p>","DOI":"10.1177\/0883073818758737","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T03:57:29Z","timestamp":1520222249000},"page":"375-382","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Isolated Optic Nerve Glioma in Children With and Without Neurofibromatosis: Retrospective Characterization and Analysis of Outcomes"],"prefix":"10.1177","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-6621","authenticated-orcid":false,"given":"Dima","family":"Hamideh","sequence":"first","affiliation":[{"name":"Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ellen","family":"Hoehn","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Surgery Department, St Jude Children\u2019s Research Hospital, Memphis, TN, USA"},{"name":"Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN, USA"},{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie H.","family":"Harreld","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, St Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Klimo","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Surgery Department, St Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Gajjar","sequence":"additional","affiliation":[{"name":"Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, TN, USA"},{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Qaddoumi","sequence":"additional","affiliation":[{"name":"Department of Oncology, St Jude Children\u2019s Research Hospital, Memphis, TN, USA"},{"name":"Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"key":"bibr1-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6701592"},{"key":"bibr2-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32831fd9f5"},{"key":"bibr3-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(94)90173-2"},{"key":"bibr4-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-011-0783-2"},{"key":"bibr5-0883073818758737","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.68.1.0085"},{"key":"bibr6-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.73.12.967"},{"key":"bibr7-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(02)00628-8"},{"key":"bibr8-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.4.516"},{"key":"bibr9-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.64.8.545"},{"key":"bibr10-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040020414016"},{"key":"bibr11-0883073818758737","doi-asserted-by":"crossref","first-page":"733","DOI":"10.4321\/S0365-66912005001200010","volume":"80","author":"Rodriguez-Francia P","year":"2005","journal-title":"Arch Soc Esp Oftalmol"},{"key":"bibr12-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000243016.90004.12"},{"key":"bibr13-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20655"},{"key":"bibr14-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/65246351"},{"key":"bibr15-0883073818758737","first-page":"1","volume":"6","author":"Neurofibromatosis","year":"1987","journal-title":"Natl Inst Health Consens Dev Conf Consens Statement"},{"key":"bibr16-0883073818758737","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1993.79.2.0223"},{"key":"bibr17-0883073818758737","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1997.86.5.0747"},{"key":"bibr18-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200305000-00005"},{"key":"bibr19-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.009"},{"key":"bibr20-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou114"},{"key":"bibr21-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1080\/08880010390232709"},{"key":"bibr22-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024278925822"},{"key":"bibr23-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80137-4"},{"key":"bibr24-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22198"},{"key":"bibr25-0883073818758737","first-page":"23","volume":"3","author":"Shamji MF","year":"2007","journal-title":"Neurosurg Focus"},{"key":"bibr26-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70159-1"},{"key":"bibr27-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180070401"},{"key":"bibr28-0883073818758737","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.68.6.0889"},{"key":"bibr29-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-016-0747-2"},{"key":"bibr30-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e318291658e"},{"key":"bibr31-0883073818758737","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70327-5"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073818758737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073818758737","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073818758737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:39:24Z","timestamp":1777495164000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073818758737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,5]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1177\/0883073818758737"],"URL":"https:\/\/doi.org\/10.1177\/0883073818758737","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,5]]}}}