{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:47:43Z","timestamp":1792853263949,"version":"4.5.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T00:00:00Z","timestamp":1522627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Friedreich Ataxia Research Alliance (FARA) and the AHEPA Family Charitable Foundation of Canada"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine how mobility device use impacts quality of life in children with Friedreich ataxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Data from 111 pediatric patients with genetically confirmed Friedreich ataxia were collected from a prospective natural history study utilizing standardized clinical evaluations, including health-related quality of life using the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Module.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Mobility device use was associated with worse mean PedsQL total, physical, emotional, social, and academic subscores, after adjusting for gender, age of disease onset, and Friedreich Ataxia Rating Scale score. The magnitude of the difference was greatest for the physical subscore (\u201319.5 points, 95% CI = \u201330.00, \u20138.99, P &lt; .001) and least for the emotional subscore (\u201310.61 points, 95% CI = \u201320.21, \u20131.02, P = .03). Transition to or between mobility devices trended toward worse physical subscore (\u201316.20 points, 95% CI = \u201332.07, \u20130.33, P = .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Mobility device use is associated with significant worsening of all domains of quality of life in children with Friedreich ataxia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073818764941","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T07:23:59Z","timestamp":1522653839000},"page":"397-404","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Mobility Device Use on Quality of Life in Children With Friedreich Ataxia"],"prefix":"10.1177","volume":"33","author":[{"given":"Resham","family":"Ejaz","sequence":"first","affiliation":[{"name":"Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Research Services, Child Health Evaluative Sciences\/Biostatistics Design & Analysis Unit, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Carnevale","sequence":"additional","affiliation":[{"name":"Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cardiomyopathy and Heart Function Program, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"George","sequence":"additional","affiliation":[{"name":"Cardiomyopathy and Heart Function Program, Labatt Family Heart Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Delatycki","sequence":"additional","affiliation":[{"name":"Murdoch Childrens Research Institute, Victorian Clinical Genetics Services, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Perlman","sequence":"additional","affiliation":[{"name":"Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine D.","family":"Mathews","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George R.","family":"Wilmot","sequence":"additional","affiliation":[{"name":"Department of Neurology, Emory University, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Chad","family":"Hoyle","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ohio State University College of Medicine, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sub H.","family":"Subramony","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Florida, College of Medicine, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Zesiewicz","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of South Florida, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M.","family":"Farmer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Neurology, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Pediatrics, Children\u2019s Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Yoon","sequence":"additional","affiliation":[{"name":"Division of Clinical and Metabolic Genetics, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Neurology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,4,2]]},"reference":[{"key":"bibr1-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.01.010"},{"key":"bibr2-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.37.1.1"},{"key":"bibr3-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24595"},{"key":"bibr4-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0184-7"},{"key":"bibr5-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.01881.x"},{"key":"bibr6-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2008.05.009"},{"key":"bibr7-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.01.002"},{"key":"bibr8-0883073818764941","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20060232"},{"key":"bibr9-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2016.10.011"},{"key":"bibr10-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000218155.46739.90"},{"key":"bibr11-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.332"},{"key":"bibr12-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000156802.15466.79"},{"key":"bibr13-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1367\/1539-4409(2003)003<0329:TPAAPP>2.0.CO;2"},{"key":"bibr14-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1081\/QEN-120001878"},{"key":"bibr15-0883073818764941","first-page":"13","author":"Kock N","year":"2012","journal-title":"J Assoc Inf Sys"},{"key":"bibr16-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.6.710"},{"key":"bibr17-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1111\/medu.12834"},{"key":"bibr18-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12938"},{"key":"bibr19-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810389043"},{"key":"bibr20-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.007"},{"key":"bibr21-0883073818764941","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.03.024"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073818764941","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073818764941","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073818764941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:39:25Z","timestamp":1777495165000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073818764941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,2]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1177\/0883073818764941"],"URL":"https:\/\/doi.org\/10.1177\/0883073818764941","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,2]]}}}