{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:16:05Z","timestamp":1793103365988,"version":"4.5.0"},"reference-count":37,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T00:00:00Z","timestamp":1524528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to show the impairment of autonomic cardiac conduction causing bradycardia and\/or electrocardiographic alterations in children affected by spinal muscular atrophy type 1 and 2 (SMA 1 and 2). Methods: We included 25 spinal muscular atrophy patients, admitted from November 2016 to May 2017. All patients underwent an electrocardiographic examination and we studied PR and QRS intervals, P-waves and QRS amplitudes, and heart rate in spinal muscular atrophy patients compared to a control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all patients, we found longer PRi and QRSi ( P &lt; .05), lower P-wave and QRS complex amplitudes ( P &lt; .01), and a decreased heart rate ( P &lt; .01) with respect to controls. When we divided our patients into SMA1 and SMA2 subgroups, we found that statistical differences were maintained for P-wave and QRS complex amplitudes and heart rate, but not for PRi and QRSi with respect to controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We suggest the hypothesis of SMN expression on cardiac tissue condition and\/or autonomic cardiac conduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073818767170","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T05:56:18Z","timestamp":1524549378000},"page":"487-492","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Electrocardiographic Evaluation in Patients With Spinal Muscular Atrophy: A Case-Control Study"],"prefix":"10.1177","volume":"33","author":[{"given":"Raffaele","family":"Falsaperla","sequence":"first","affiliation":[{"name":"General Pediatrics and Pediatric Acute and Emergency Complex Unit, Policlinico-Vittorio-Emanuele University Hospital, University of Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4181-6287","authenticated-orcid":false,"given":"Giovanna","family":"Vitaliti","sequence":"additional","affiliation":[{"name":"General Pediatrics and Pediatric Acute and Emergency Complex Unit, Policlinico-Vittorio-Emanuele University Hospital, University of Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ausilia Desiree","family":"Collotta","sequence":"additional","affiliation":[{"name":"General Pediatrics and Pediatric Acute and Emergency Complex Unit, Policlinico-Vittorio-Emanuele University Hospital, University of Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Unit of Paediatric Neurology and Muscle Diseases, G. Gaslini Institute, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Pulvirenti","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Bioinformatics, University of Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Alaimo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Section of Bioinformatics, University of Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Romano","sequence":"additional","affiliation":[{"name":"General Pediatrics and Pediatric Acute and Emergency Complex Unit, Policlinico-Vittorio-Emanuele University Hospital, University of Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Unit of Rare Diseases of the Nervous System 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