{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:30:32Z","timestamp":1791725432857,"version":"4.3.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T00:00:00Z","timestamp":1532217600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n                    There have been few case reports showing association of vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency with infantile spasms. We planned this study to see if there was an association of serum vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency in children with development of infantile spasms. Cases included children with infantile spasms of ages 6 months to 3 years. The controls were children in the same age group who had global developmental delay but no history of epileptic spasms. Mean serum vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    , serum homocysteine, and urinary methylmalonic acid levels were measured in both groups and compared. Children with infantile spasms had lower mean serum vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    levels (354.1 pg\/mL; standard deviation 234.1 pg\/mL) as compared to children with global developmental delay without spasms (466.7 pg\/mL; standard deviation 285.5 pg\/mL) ( P value &lt; .05). Mean serum homocysteine level (13.9 vs 7.8 \u03bcmol\/L, P = .02) and mean urinary methylmalonic acid level (68.1 mmol\/mol of creatinine vs 26.1 mmol\/mol of creatinine, P = .03) were elevated in children with infantile spasms than in controls. Fourteen children (35.0%) with infantile spasms were vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficient compared with 3 (7.50%) controls ( P = .005). Thus, vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    deficiency may have an association with infantile spasms. More studies are needed before recommending routine measurement of serum B\n                    <jats:sub>12<\/jats:sub>\n                    levels in children with infantile spasms.\n                  <\/jats:p>","DOI":"10.1177\/0883073818787062","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:50:36Z","timestamp":1532307036000},"page":"767-771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Vitamin B\n                    <sub>12<\/sub>\n                    Deficiency in Children With Infantile Spasms: A Case-Control Study"],"prefix":"10.1177","volume":"33","author":[{"given":"Mahender K.","family":"Meena","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvasini","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himani","family":"Bhasin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satinder","family":"Aneja","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,22]]},"reference":[{"key":"bibr1-0883073818787062","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02657.x"},{"key":"bibr2-0883073818787062","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2013.04.014"},{"key":"bibr3-0883073818787062","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00774.x"},{"key":"bibr4-0883073818787062","first-page":"122","volume":"52","author":"Kumar 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