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This review highlights the similarities between migraine and epilepsy in pediatrics, focusing on epidemiologic, pathophysiological, genetic, clinical, and pharmacologic aspects. Despite the fact that several syndromes share symptoms of both migraine and epilepsy, further research is needed to clarify the pathophysiological and genetic basis of their comorbidity. Drugs used for prophylactic therapy of migraine and epilepsy have similar pharmacologic properties. The role of epileptic pharmacotherapy in the prophylaxis of migraine is assessed, including the use of conventional antiepileptic drugs, calcium channel blockers, and nonpharmacologic methods such as dietary therapy, supplements, and vagal nerve stimulation. Further randomized, controlled clinical trials assessing pharmacologic and nonpharmacologic methods for the treatment of both disorders are essential, in order to initiate new therapeutic approaches.<\/jats:p>","DOI":"10.1177\/0883073818788942","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T06:54:28Z","timestamp":1533884068000},"page":"801-808","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Comorbidity of Migraine and Epilepsy in Pediatrics: A Review"],"prefix":"10.1177","volume":"33","author":[{"given":"Jasna","family":"Jancic","sequence":"first","affiliation":[{"name":"Clinic of Neurology and Psychiatry for Children and Youth, Medical Faculty, University of Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Djuric","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Belgrade, 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