{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:17:42Z","timestamp":1778696262356,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>Guillain-Barr\u00e9 syndrome (GBS) is the most common cause of acute flaccid paralysis in children. During the acute phase, the disorder can be life-threatening by involving the respiratory muscles and the autonomic nervous system. Nevertheless, the prognosis is good, and most children achieve full recovery. The aim of this study was to characterize the clinical and electrophysiologic findings in children with Guillain-Barr\u00e9 syndrome referred to a tertiary center in Israel. A retrospective database review from 2009 to 2015 identified 39 children. Data on clinical presentation, respiratory complications, and long-term neurologic outcomes were collected. Atypical clinical findings at admission included asymmetric weakness in 23%, nonascending weakness in 30%, and normal deep tendon reflexes in 28%. Eight children were later diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Electrophysiologic findings, available in 12 patients with Guillain-Barr\u00e9 syndrome, revealed acute inflammatory demyelinating polyradiculoneuropathy (AIDP) in 4 (33.5%), AIDP with secondary axonal changes in 3 (25%), and acute motor axonal neuropathy (AMAN) subtype in 4 (33.5%); 8% had no abnormal findings. On follow-up, 71% of the children with Guillain-Barr\u00e9 syndrome fully recovered compared to 14% of the children with CIDP. Corresponding rates of neurologic sequelae were 29% and 86%. Clinicians should be alert to the atypical presenting symptoms of Guillain-Barr\u00e9 syndrome, which occur in a significant proportion of children.<\/jats:p>","DOI":"10.1177\/0883073818825213","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T01:56:54Z","timestamp":1548295014000},"page":"268-276","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Atypical Clinical Presentations of Pediatric Acute Immune-Mediated Polyneuropathy"],"prefix":"10.1177","volume":"34","author":[{"given":"Naama","family":"Yosha-Orpaz","sequence":"first","affiliation":[{"name":"Pediatric Neurology Unit, Edith Wolfson Medical Center, Holon, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Aharoni","sequence":"additional","affiliation":[{"name":"Institute of Child Neurology, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Rabie","sequence":"additional","affiliation":[{"name":"Institute of Child Neurology, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoram","family":"Nevo","sequence":"additional","affiliation":[{"name":"Institute of Child Neurology, Schneider Children\u2019s Medical Center of Israel, Petach Tikva, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328365ad3f"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1114525"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2008.04.009"},{"key":"e_1_3_2_5_2","first-page":"1086","volume-title":"Swaiman\u2019s Pediatric Neurology Principles and Practice","author":"Rabie M","year":"2018","unstructured":"Rabie M, Ashwal S, Nevo Y. Inflammatory neuropathies. In: Swaiman KF, Ashwal S, Ferriero DM, , eds. Swaiman\u2019s Pediatric Neurology Principles and Practice. 6th ed. Philadelphia, PA: Elsevier; 2018:1086\u20131091.","edition":"6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000265396.87983.bd"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-8994(96)00253-6"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2007.00949.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410270707"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.003"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001391"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-07-441857"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.Supplement_1.S160"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2014-001044"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(01)00286-3"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.33-4-164"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1324"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-006-0710-z"},{"issue":"4","key":"e_1_3_2_20_2","first-page":"17","article-title":"Atypical findings of Guillain-Barr\u00e9 syndrome in children","volume":"6","author":"Karimzadeh P","year":"2012","unstructured":"Karimzadeh P, Bakhshande Bali MK, Nasehi MM, Taheri Otaghsara SM, Ghofrani M. Atypical findings of Guillain-Barr\u00e9 syndrome in children. Iran J Child Neurol. 2012;6(4):17\u201322.","journal-title":"Iran J Child Neurol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6330-4"},{"issue":"3","key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/0883073804019003.191","article-title":"Guillain-Barr\u00e9 syndrome in children","volume":"19","author":"Sladky JT","year":"2004","unstructured":"Sladky JT. Guillain-Barr\u00e9 syndrome in children. J Child Neurol. 2004;19(3):191\u2013200.","journal-title":"J Child Neurol"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-981686"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12068"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073818825213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073818825213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073818825213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:39:47Z","timestamp":1777495187000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073818825213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,23]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1177\/0883073818825213"],"URL":"https:\/\/doi.org\/10.1177\/0883073818825213","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,23]]}}}