{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:33:00Z","timestamp":1777804380436,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T00:00:00Z","timestamp":1557360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Adult Biomarkers in Neonatal Brain Injury and Development","award":["1 R01 HD086058-01A1"],"award-info":[{"award-number":["1 R01 HD086058-01A1"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Hypoxic-ischemic encephalopathy is associated with damage to deep gray matter; however, white matter involvement has become recognized. This study explored differences between patients and clinical controls on diffusion tensor imaging, and relationships between diffusion tensor imaging and neurodevelopmental outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Diffusion tensor imaging was obtained for 31 neonates after hypoxic-ischemic encephalopathy treated with therapeutic hypothermia and 10 clinical controls. A subgroup of patients with hypoxic-ischemic encephalopathy (n = 14) had neurodevelopmental outcomes correlated with diffusion tensor imaging scalars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Group differences in diffusion tensor imaging scalars were observed in the putamen, anterior and posterior centrum semiovale, and the splenium of the corpus callosum. Differences in these regions of interest were correlated with neurodevelopmental outcomes between ages 20 and 32 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Therapeutic hypothermia may not be a complete intervention for hypoxic-ischemic encephalopathy, as neonatal white matter changes may continue to be evident, but further research is warranted. Patterns of white matter change on neonatal diffusion tensor imaging correlated with neurodevelopmental outcomes in this exploratory pilot study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073819841717","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T07:02:20Z","timestamp":1557385340000},"page":"556-566","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Correlation Between White Matter Injury Identified by Neonatal Diffusion Tensor Imaging and Neurodevelopmental Outcomes Following Term Neonatal Asphyxia and Therapeutic Hypothermia: An Exploratory Pilot Study"],"prefix":"10.1177","volume":"34","author":[{"given":"Gwendolyn J.","family":"Gerner","sequence":"first","affiliation":[{"name":"Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric I.","family":"Newman","sequence":"additional","affiliation":[{"name":"Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Joanna","family":"Burton","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenton","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Cristofalo","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Frederick Memorial Hospital, Department of Neonatology, Frederick, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Leppert","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, Baltimore, MD, USA"},{"name":"Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Hugo Moser Research Institute, Kennedy Krieger Institute, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances J.","family":"Northington","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Department of Perinatal-Neonatal Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry A.G.M.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Neurosciences Intensive Care Nursery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA"},{"name":"Section of Pediatric Neuroradiology, Division of Pediatric Radiology, Russell H. 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