{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:22:54Z","timestamp":1784128974491,"version":"3.55.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To investigate etiology and prognostic significance of pontine tegmentum lesions accompanying a cluster of acute flaccid myelitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We retrospectively examined patients from 6 centers in Turkey who manifested encephalitis or myelitis associated with dorsal pontine lesions on magnetic resonance imaging (MRI) between July 2018 and February 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-two patients were evaluated. Ten of 22 (45%) presented with acute paralysis and 12 of 22 (55%) with brainstem symptoms only. Reverse transcription polymerase chain reaction for enterovirus was positive in 2 patients\u2019 respiratory tract. Other etiologic factors were detected in 10 cases. On follow-up, patients presenting with symptoms of myelitis developed motor sequalae although spinal cord lesions on MRI resolved in 5 of 9 (55%). Encephalitic symptoms, present in 17 cases, recovered in 13 (76%), and brain MRI showed complete or near-complete resolution in 11 of 14 (78%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Various etiologic agents can be detected in patients with pontine involvement, even in a series collected during an outbreak of EV-D68. Encephalitis has a fair outcome but clinical recovery is slow and motor sequalae are frequent in spinal involvement, irrespective of follow-up spinal MRI findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073820911737","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T11:08:15Z","timestamp":1591528095000},"page":"501-508","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Pontine Tegmentum Lesions Accompanying Myelitis During an Enterovirus Outbreak: Differential Diagnosis and Outcome"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-6921","authenticated-orcid":false,"given":"Mehmet","family":"Bastemur","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Ihsan Do\u011framaci Children\u2019s Hospital, Faculty of Medicine, Hacettepe University, Ankara"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahsan","family":"Gocmen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6028-4653","authenticated-orcid":false,"given":"Safak","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Yuksel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Dr. Sami Ulus Children\u2019s Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif Acar","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Karadeniz Technical University Trabzon, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arzu Yilmaz","family":"Okten","sequence":"additional","affiliation":[{"name":"Ankara Training and Research Hospital, Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin","family":"Iscan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Faculty of Medicine, Bezmialem Vak\u0131f University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baris","family":"Ekici","sequence":"additional","affiliation":[{"name":"Child Neurology Clinic, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Anlar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Ihsan Do\u011framaci Children\u2019s Hospital, Faculty of Medicine, Hacettepe University, Ankara"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"key":"bibr1-0883073820911737","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.17275"},{"key":"bibr2-0883073820911737","unstructured":"US Centers for Disease Control and Prevention. Acute flaccid myelitis\u2014AFM investigation. https:\/\/www.cdc.gov\/acute-flaccid-myelitis\/afm-surveillance.html. Accessed October 23, 2018."},{"key":"bibr3-0883073820911737","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6745e1"},{"key":"bibr4-0883073820911737","unstructured":"Centers for Disease Control and Prevention. Acute flaccid myelitis: interim considerations for clinical management. www.cdc.gov\/ncird\/downloads\/acute-flaccid-myelitis.pdf. 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