{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:41:06Z","timestamp":1790163666466,"version":"4.1.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>In young children, excessive cow\u2019s milk intake causes iron-deficiency anemia, which is associated with hypercoagulable states. We present a case series of 4 toddlers with excessive milk intake iron-deficiency anemia and cerebral sinovenous thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective chart review of 4 patients was performed for patients with cerebral sinovenous thrombosis and iron-deficiency anemia secondary to excessive milk intake. Iron-deficiency anemia was defined as hemoglobin &lt;11 mg\/dL, mean corpuscular volume &lt;70 fL, and serum ferritin &lt;12 \u03bcg\/L. Excessive milk intake was defined as consumption of &gt;24 oz daily. Clinical, laboratory, and radiographic features were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Age ranged from 12 to 24 months. Average hemoglobin, hematocrit, mean corpuscular volume, and ferritin levels were 6.1 g\/dL, 22.7 g\/dL, 52.7 fL, and 3.2 ng\/mL, respectively. Daily milk consumption ranged from 40 to 60 oz. All patients presented with focal neurologic deficits, including seizures in 3. The location of cerebral sinovenous thrombosis varied, and 3 patients had venous infarcts, one of them hemorrhagic. All patients had a limited diet and were described as \u201cpicky eaters\u201d by their parents, and only 1 had transitioned of a bottle. All patients were treated with anticoagulation, iron supplementation, and extensive dietary counseling to reduce cow\u2019s milk intake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Iron-deficiency anemia due to excessive milk intake is an important and preventable etiology of pediatric cerebral sinovenous thrombosis. Focused anticipatory guidance is necessary for at-risk groups to prevent this neurologic emergency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073820923807","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T02:56:58Z","timestamp":1589943418000},"page":"585-590","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Too Much of a Good Thing? Cerebral Sinovenous Thrombosis Due to Excessive Milk Intake Associated Anemia"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8717-7703","authenticated-orcid":false,"given":"Raquel","family":"Farias-Moeller","sequence":"first","affiliation":[{"name":"Division of Child Neurology, Department of Neurology, Medical College of Wisconsin, Children\u2019s Wisconsin, Milwaukee, WI, USA"},{"name":"Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Children\u2019s Wisconsin, Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Neurology, Medical College of Wisconsin, Children\u2019s Wisconsin, Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Orr","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lileth","family":"Mondok","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Neurology, Medical College of Wisconsin, Children\u2019s Wisconsin, Milwaukee, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"bibr1-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.10.024"},{"key":"bibr2-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005030226"},{"key":"bibr3-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.080"},{"key":"bibr4-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082952"},{"key":"bibr5-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000249"},{"key":"bibr6-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0502"},{"key":"bibr7-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1972.00320030103013"},{"key":"bibr8-0883073820923807","first-page":"2012","volume":"487080","author":"Mehta PJ","year":"2012","journal-title":"Case Rep Neurol Med"},{"key":"bibr9-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2018.1452456"},{"key":"bibr10-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2001.01329.x"},{"key":"bibr11-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-007-0416-1"},{"key":"bibr12-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1922-y"},{"key":"bibr13-0883073820923807","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00431.x"},{"key":"bibr14-0883073820923807","unstructured":"American Academy of Pediatrics. 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