{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:31:47Z","timestamp":1777804307114,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"13","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neurotuberculosis is among the most severe type of tuberculosis with high mortality and morbidity in all age groups. Various sociodemographic and disease-\/treatment-related factors have emerged over the years that can affect clinical and radiologic features of neurotuberculosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate various clinical and neuroradiologic presentations of neurotuberculosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>This cross-sectional study was done in a tertiary care center of northern India. The patients between the ages of 3 months and 18 years with newly diagnosed neurotuberculosis were enrolled after taking informed consent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 78 patients (37% males) were enrolled. Fifty-six patients (72%) had tubercular meningitis (TBM) and 22 (28%) isolated tuberculomas. Very high percentage of patients in both the groups was BCG vaccinated. In the tubercular meningitis group, fever (68%), headache (59%), and vomiting (54%) were the most common complaints whereas in the tuberculoma group, seizures (95.5%) were the main complaint and systemic symptoms were rare. In tubercular meningitis patients, cerebrospinal fluid\u2013based studies showed cartridge-based nucleic acid amplification test (Xpert MTB\/RIF) positivity for Mycobacterium tuberculosis in 17.6% cases, whereas on gastric aspirate and sputum examination, acid-fast bacilli were seen in 30.7% and cartridge-based nucleic acid amplification test was positive in 19% patients. On neuroimaging, hydrocephalus was seen in 44.6% of tubercular meningitis patients, infarcts in 32%, and basal exudates in 12% patients only; coexistent tuberculomas were seen in 53%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Compared with the available literature, the present study showed a smaller percentage of children &lt;5 years of age, stage III tubercular meningitis cases, and typical neuroradiologic findings like hydrocephalus and basal exudates and more tuberculomas associated with tubercular meningitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073820938594","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T07:59:48Z","timestamp":1594972788000},"page":"879-888","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Changing Clinicoradiologic Spectrum of Intracranial Neurotuberculosis in Children: A Cross-sectional Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Sumiti","family":"Banga","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2186-839X","authenticated-orcid":false,"given":"Chandrika","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rekha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nishit","family":"Sawal","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidushi","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdish","family":"Chander","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishal","family":"Guglani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Government Medical College and Hospital, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"bibr1-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-76660-5_5"},{"key":"bibr2-0883073820938594","doi-asserted-by":"publisher","DOI":"10.4103\/0976-3147.181475"},{"issue":"4","key":"bibr3-0883073820938594","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0033-8389(22)00616-9","volume":"33","author":"Dastur DK","year":"1995","journal-title":"Radiol Clin North Am"},{"key":"bibr4-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1007\/BF02751703"},{"key":"bibr5-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(10)70138-9"},{"key":"bibr6-0883073820938594","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_288_19"},{"key":"bibr7-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001772"},{"key":"bibr8-0883073820938594","doi-asserted-by":"publisher","DOI":"10.5114\/pjr.2018.81408"},{"key":"bibr9-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-018-0726-9"},{"key":"bibr10-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.08.3258"},{"key":"bibr11-0883073820938594","unstructured":"World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity [Internet]. WHO. http:\/\/www.who.int\/vmnis\/indicators\/haemoglobin\/en\/."},{"key":"bibr12-0883073820938594","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1145_19"},{"key":"bibr13-0883073820938594","unstructured":"World Health Organization. Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB\/RIF assays for the diagnosis of pulmonary and extrapulmonary TB in adults and children Policy update WHO\/HTM\/TB\/201316. Accessed April 10, 2020."},{"key":"bibr14-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(70)90187-5"},{"key":"bibr15-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1007\/BF00688161"},{"key":"bibr16-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.09.004"},{"key":"bibr17-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-015-0186-7"},{"key":"bibr18-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6839-6.10148-0"},{"key":"bibr19-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1923-2"},{"issue":"6","key":"bibr20-0883073820938594","first-page":"641","volume":"32","author":"Thilothammal N","year":"1995","journal-title":"Indian Pediatr"},{"key":"bibr21-0883073820938594","doi-asserted-by":"publisher","DOI":"10.4103\/mjmsr.mjmsr_33_17"},{"issue":"5","key":"bibr22-0883073820938594","first-page":"455","volume":"36","author":"Awasthi S","year":"1999","journal-title":"Indian Pediatr"},{"key":"bibr23-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.5.e49"},{"key":"bibr24-0883073820938594","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.16407"},{"key":"bibr25-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1353"},{"key":"bibr26-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0692"},{"key":"bibr27-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1177\/0883073819884169"},{"key":"bibr28-0883073820938594","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1745.85725"},{"key":"bibr29-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/S0377-1237(17)30952-8"},{"key":"bibr30-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(00)00190-X"},{"key":"bibr31-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-018-2811-0"},{"key":"bibr32-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.75.881.133"},{"key":"bibr33-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2005.03.001"},{"key":"bibr34-0883073820938594","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2007.08.024"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073820938594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073820938594","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073820938594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:39:37Z","timestamp":1777495177000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073820938594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,17]]},"references-count":34,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1177\/0883073820938594"],"URL":"https:\/\/doi.org\/10.1177\/0883073820938594","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,17]]}}}