{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:09:44Z","timestamp":1780625384683,"version":"3.54.1"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Department of Pediatrics, Baystate Children\u2019s Hospital, UMMS-Baystate"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:p>Currently used treatment protocols for neonatal seizures vary among centers with limited evidence to support the choice of a given antiseizure medication. Because of concerns about the potential negative impact of phenobarbital on long-term neurodevelopment outcomes, our unit transitioned to fosphenytoin as the first-line antiseizure medication. A retrospective observational cohort study was conducted to compare the acute and long-term outcomes of fosphenytoin and phenobarbital as first-line antiseizure medication for neonatal seizure treatment. The 2 study groups had similar baseline characteristics for neonatal variables as well as maternal antenatal complications. We did not find any differences in the acute outcomes between the 2 groups. However, significantly fewer infants in the fosphenytoin group had moderate-to-severe neurodevelopmental delay at the 18- and 24-month assessments. In conclusion, although both medications were equally efficacious for acute neonatal seizure control, fosphenytoin had the potential for significantly better neurodevelopmental outcomes at 18-24 months of age.<\/jats:p>","DOI":"10.1177\/0883073820947514","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T04:28:58Z","timestamp":1597811338000},"page":"30-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Efficacy of Fosphenytoin as First-Line Antiseizure Medication for Neonatal Seizures Compared to Phenobarbital"],"prefix":"10.1177","volume":"36","author":[{"given":"Veronica","family":"Alix","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Baystate Children\u2019s Hospital, UMMS-Baystate, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"James","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baystate Children\u2019s Hospital, UMMS-Baystate, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony H.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baystate Children\u2019s Hospital, UMMS-Baystate, Springfield, MA, USA"},{"name":"Department of Neurology, UMMS-Baystate, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Visintainer","sequence":"additional","affiliation":[{"name":"Epidemiology & Biostatistics, Office of Research, UMMS-Baystate, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7783-1214","authenticated-orcid":false,"given":"Rachana","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baystate Children\u2019s Hospital, UMMS-Baystate, Springfield, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"bibr1-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.01.041"},{"key":"bibr2-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14537"},{"key":"bibr3-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31823e96d7"},{"key":"bibr4-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2013.05.008"},{"key":"bibr5-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.12.1837"},{"key":"bibr6-0883073820947514","first-page":"301","volume":"28","author":"Agrawal A","year":"2017","journal-title":"Indian J Clin Pract"},{"key":"bibr7-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305206"},{"key":"bibr8-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3777"},{"key":"bibr9-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.4.506"},{"key":"bibr10-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2004.11.005"},{"key":"bibr11-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.03.040"},{"key":"bibr12-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13365"},{"key":"bibr13-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.126250"},{"key":"bibr14-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222550499"},{"key":"bibr15-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24967"},{"key":"bibr16-0883073820947514","doi-asserted-by":"publisher","DOI":"10.5698\/1535-7597.18.1.51"},{"key":"bibr17-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21167"},{"key":"bibr18-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2018.02.005"},{"key":"bibr19-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-3182"},{"key":"bibr20-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1177\/0883073817745990"},{"key":"bibr21-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.022"},{"key":"bibr22-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2017.03.006"},{"key":"bibr23-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13990"},{"key":"bibr24-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14671"},{"key":"bibr25-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-012-0005-1"},{"key":"bibr26-0883073820947514","unstructured":"Abend NS, Jensen FE, Inder TE, et al. Neonatal Seizures. Volpe\u2019s Neurology of the Newborn. 6th ed. 2020;Unit III Chapter 12:273\u2013322."},{"key":"bibr27-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1177\/0883073898013001061"},{"key":"bibr28-0883073820947514","first-page":"153","volume":"20","author":"Diaz J","year":"1977","journal-title":"Proc West Pharmacol Soc"},{"key":"bibr29-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(75)90083-7"},{"key":"bibr30-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(83)90233-9"},{"key":"bibr31-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1177\/0883073812470734"},{"key":"bibr32-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-012-0005-1"},{"key":"bibr33-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808321056"},{"key":"bibr34-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410704"},{"key":"bibr35-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000106944.59990.E6"},{"key":"bibr36-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1038\/nm1301"},{"key":"bibr37-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.022"},{"key":"bibr38-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.116"},{"key":"bibr39-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002083220604"},{"key":"bibr40-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000279335.85797.2c"},{"key":"bibr41-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.03.057"},{"key":"bibr42-0883073820947514","doi-asserted-by":"publisher","DOI":"10.4103\/jpn.JPN_172_16"},{"key":"bibr43-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-018-1103-1"},{"key":"bibr44-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-3182"},{"key":"bibr45-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-019-1441-7"},{"key":"bibr46-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0554-7"},{"key":"bibr47-0883073820947514","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-018-0242-2"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073820947514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073820947514","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073820947514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:39:40Z","timestamp":1777495180000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073820947514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1177\/0883073820947514"],"URL":"https:\/\/doi.org\/10.1177\/0883073820947514","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]}}}