{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:29:16Z","timestamp":1780320556925,"version":"3.54.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"14","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Gregory S. and Elizabeth Wahl Research Fund in Rare, Undiagnosed and Complex Childhood Diseases","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose:<\/jats:title>\n                    <jats:p>Postural orthostatic tachycardia syndrome has been recognized for decades, but treatment is largely based on anecdotal experience and expert opinion. Pharmacologic treatment is inconsistent and unstandardized. We did a systematic review to identify controlled studies from which informed treatment decisions can be made.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Through a standard systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we identified all English-language studies of a medication treatment for postural orthostatic tachycardia syndrome that included a comparison or control group and followed outcomes for at least 1 week of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 626 studies were identified by the search criteria, and 8, involving a total of 499 patients, met the criteria. No studies were adequately similar to allow for meta-analysis. Of the identified 8 studies, 2 were randomized controlled trials and 4 had been subjected to peer review. In individual studies, there was some favorable effect with fludrocortisone, beta blockers, midodrine, and selective serotonin reuptake inhibitors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is a paucity of high-quality data about effectiveness of medication in the treatment of postural orthostatic tachycardia syndrome. Nonetheless, 2 randomized trials and 6 other reports show some favorable effects of medication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073820948679","type":"journal-article","created":{"date-parts":[[2020,8,25]],"date-time":"2020-08-25T02:13:59Z","timestamp":1598321639000},"page":"1004-1016","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Treatment of Postural Orthostatic Tachycardia Syndrome With Medication: A Systematic Review"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9531-4990","authenticated-orcid":false,"given":"Bashar","family":"Hasan","sequence":"first","affiliation":[{"name":"Evidence-Based Practice Research Program, Mayo Clinic, MN, USA"},{"name":"Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehad","family":"Almasri","sequence":"additional","affiliation":[{"name":"Evidence-Based Practice Research Program, Mayo Clinic, MN, USA"},{"name":"Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, MN, USA"},{"name":"Department of Internal Medicine, Piedmont Athens Regional Hospital, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bilal","family":"Marwa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey M.","family":"Klaas","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"bibr1-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2009.07.002"},{"key":"bibr2-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1016\/j.cppeds.2013.12.014"},{"key":"bibr3-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.013"},{"key":"bibr4-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-1673"},{"key":"bibr5-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.02.035"},{"key":"bibr6-0883073820948679","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00261"},{"issue":"2","key":"bibr7-0883073820948679","first-page":"103","volume":"1","author":"Lambert E","year":"2008","journal-title":"Circulation"},{"issue":"5","key":"bibr8-0883073820948679","first-page":"229","volume":"22","author":"Mehta N","year":"2012","journal-title":"Clin Autonomic Res"},{"key":"bibr9-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31826d5f95"},{"key":"bibr10-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2012.05.002"},{"key":"bibr11-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12067"},{"key":"bibr12-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1177\/0269881113512911"},{"key":"bibr13-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.846501"},{"key":"bibr14-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2011.03047.x"},{"key":"bibr15-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3181ef621a"},{"key":"bibr16-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0000000000000468"},{"key":"bibr17-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13182"},{"key":"bibr18-0883073820948679","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"bibr19-0883073820948679","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","author":"Higgins J","year":"2011"},{"key":"bibr20-0883073820948679","unstructured":"Wells G, Shea B, O\u2019Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp. Published 2017. Accessed August 2, 2017."},{"key":"bibr21-0883073820948679","volume-title":"Annals of Pediatric Cardiology. Paper presented at: 5th Congress of the Asia-Pacific Pediatric Cardiac Society, APPCS 2014","author":"Yang Y"},{"key":"bibr22-0883073820948679","volume-title":"Paper presented at: 72nd Annual Scientific Meeting of the American Psychosomatic Society","author":"Yamada U"},{"key":"bibr23-0883073820948679","volume-title":"Conference Abstract presented at Hypertension. 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