{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:13:22Z","timestamp":1785366802606,"version":"3.55.0"},"reference-count":48,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1R01HD081120-01A1"],"award-info":[{"award-number":["1R01HD081120-01A1"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To examine associations between the deep medullary vein white matter injury global severity scoring system and neurodevelopmental impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a prospective observational cohort study of infants born at \u226532 weeks, diagnosed with deep medullary vein thrombosis and infarction on neuroimaging in the first month of life. Developmental testing was performed using validated measures for early, preschool, and school-age follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Nineteen (37%) patients had major neurodevelopmental impairment. Global severity score was higher among patients with neurodevelopmental impairment (21.6 vs 13.4, P = .04). Overall, 78% of patients with epilepsy had neurodevelopmental impairment. A greater degree of asymmetry with right-sided injury predominance was associated with lower Bayley-III cognitive scores and presence of neurodevelopmental impairment ( P &lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Results suggest a need for targeted clinical surveillance for patients with a high global severity score and\/or asymmetric, predominantly right cerebral white matter injury and for those who develop epilepsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073820967161","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T05:14:47Z","timestamp":1612156487000},"page":"253-261","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Deep Medullary Vein White Matter Injury Global Severity Score Predicts Neurodevelopmental Impairment"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-2737","authenticated-orcid":false,"given":"Kristen L.","family":"Benninger","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-1085","authenticated-orcid":false,"given":"Tara L.","family":"Benninger","sequence":"additional","affiliation":[{"name":"Department of Behavioral Health, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Moore-Clingenpeel","sequence":"additional","affiliation":[{"name":"Biostatistics Core, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-610X","authenticated-orcid":false,"given":"Lynne","family":"Ruess","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome A.","family":"Rusin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-9302","authenticated-orcid":false,"given":"Nathalie L.","family":"Maitre","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,2,1]]},"reference":[{"key":"bibr1-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450604"},{"key":"bibr2-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811408094"},{"key":"bibr3-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2016.12.008"},{"key":"bibr4-0883073820967161","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2687"},{"key":"bibr5-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2017160061"},{"key":"bibr6-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1789.1999.00215.x"},{"key":"bibr7-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.03.051"},{"key":"bibr8-0883073820967161","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5940"},{"key":"bibr9-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.583542"},{"key":"bibr10-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.003"},{"key":"bibr11-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.3.405"},{"key":"bibr12-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2009.07.010"},{"key":"bibr13-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2019.02.013"},{"key":"bibr14-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13047"},{"key":"bibr15-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12187"},{"key":"bibr16-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811408090"},{"key":"bibr17-0883073820967161","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"bibr18-0883073820967161","unstructured":"Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network. 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