{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:34:35Z","timestamp":1793921675605,"version":"4.8.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neonatal bacterial meningitis has high rates of morbidity and mortality. Early clinical signs and neuroimaging suggest adverse outcomes, but little is known about their combined predictive properties. We evaluated the combination of findings most associated with death and neurodevelopmental impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Single-center retrospective cohort study of term and late preterm neonates with bacterial meningitis. Predictors of death and neurodevelopmental impairment were identified on univariate analysis and incorporated into Lasso models to identify variables best predicting adverse outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 103 neonates, 6 died acutely; 30% of survivors had neurodevelopmental impairment. Clinical variables (seizures, pressor support) predicted death and neurodevelopmental impairment better than the neuroimaging or combined findings (area under the curve 0.88 vs 0.79 and 0.83, respectively). Among survivors, neuroimaging findings (cerebrovascular lesions, ventriculomegaly) predicted neurodevelopmental impairment better than clinical or combined findings (area under the curve 0.82 vs 0.80 and 0.77, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Seizures are important predictors of adverse outcomes in neonatal bacterial meningitis. Among survivors, neuroimaging findings help predict neurodevelopmental impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738211026053","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:33:23Z","timestamp":1626222803000},"page":"968-973","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Predictors of Neurodevelopmental Impairment After Neonatal Bacterial Meningitis"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3149-259X","authenticated-orcid":false,"given":"Darrah N.","family":"Haffner","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, Nationwide Children\u2019s Hospital and the Ohio State University, Columbus, OH, USA"},{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical School\/Children\u2019s Health, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Machie","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical School\/Children\u2019s Health, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Hone","sequence":"additional","affiliation":[{"name":"Biostatistics Core, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana R.","family":"Said","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, University of Texas Southwestern Medical School\/Children\u2019s Health, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8520-9302","authenticated-orcid":false,"given":"Nathalie L.","family":"Maitre","sequence":"additional","affiliation":[{"name":"Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Division of Neonatology, Department of Pediatrics, Nationwide Children\u2019s Hospital and the Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.10.004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0204-6_2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9020377"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000720"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ367"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70332-3"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.3.477"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3453"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14593"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.11.002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306191"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00929"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-10-232"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.086314"},{"key":"e_1_3_2_16_2","first-page":"32","article-title":"Acute symptomatic seizures in neonates","volume":"100768","author":"Glass HC","year":"2019","unstructured":"Glass HC, Shellhaas RA. 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