{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:35:04Z","timestamp":1777804504808,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Although multiple neurologic manifestations associated with SARS-CoV-2 infection have been described in adults, there is little information about those presented in children. Here, we described neurologic manifestations associated with COVID-19 in the pediatric population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Retrospective case series report. We included patients younger than 18 years, admitted with confirmed SARS-CoV-2 infection and neurologic manifestations at our hospital in Santiago, Chile. Demographics, clinical presentations, laboratory results, radiologic and neurophysiological studies, treatment, and outcome features were described. Cases were described based on whether they presented with predominantly central or peripheral neurologic involvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Thirteen of 90 (14.4%) patients admitted with confirmed infection presented with new-onset neurologic symptoms and 4 patients showed epilepsy exacerbation. Neurologic manifestations ranged from mild (headache, muscle weakness, anosmia, ageusia), to severe (status epilepticus, Guillain-Barr\u00e9 syndrome, encephalopathy, demyelinating events).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We found a wide range of neurologic manifestations in children with confirmed SARS-CoV-2 infection. In general, neurologic symptoms were resolved as the systemic presentation subsided. It is essential to recognize and report the main neurologic manifestations related to this new infectious disease in the pediatric population. More evidence is needed to establish the specific causality of nervous system involvement.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073821989164","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T13:40:20Z","timestamp":1614606020000},"page":"853-866","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":46,"title":["Neurologic Features Associated With SARS-CoV-2 Infection in Children: A Case Series Report"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3919-9240","authenticated-orcid":false,"given":"Francisca","family":"Sandoval","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Julio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-4428","authenticated-orcid":false,"given":"Gast\u00f3n","family":"M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Valderas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra C.","family":"Echeverr\u00eda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Perinetti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Mario","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Barraza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidad de Santiago de Chile, Santiago, Chile"},{"name":"Electromyography and Evoked Potentials Unit, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Pi\u00f1era","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Regi\u00f3n Metropolitana, Chile"},{"name":"Faculty of Medicine, Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macarena","family":"Alarc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"},{"name":"Faculty of Medicine, Universidad de Santiago de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Samaniego","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00eda","family":"Quesada-Rios","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Santiago, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Robles","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Regi\u00f3n Metropolitana, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giannina","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Dr. Exequiel Gonz\u00e1lez Cort\u00e9s, Regi\u00f3n Metropolitana, Chile"},{"name":"Faculty of Medicine, Universidad de Chile, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,1]]},"reference":[{"key":"bibr1-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"bibr2-0883073821989164","unstructured":"World Health Organization. Naming the coronavirus disease (COVID-19) and the virus that causes it. https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/technical-guidance\/naming-the-coronavirus-disease-(covid-2019)-and-the-virus-that-causes-it . Published 2020. Accessed July 18, 2020."},{"key":"bibr3-0883073821989164","unstructured":"Departamento de Epidemiolog\u00eda MINSAL. Informe epidemiol\u00f3gico N\u00b0 33 Enfermedad por SARS-CoV-2 (COVID-19) Chile. https:\/\/www.minsal.cl\/wp-content\/uploads\/2020\/07\/InformeEPI130720.pdf. Published July 13, 2020. Accessed July 20, 2020."},{"key":"bibr4-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-020-03684-7"},{"key":"bibr5-0883073821989164","unstructured":"World Health Organization. Multisystem inflammatory syndrome in children and adolescents with COVID-19: scientific brief. https:\/\/www.who.int\/publications-detail\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-COVID-19. Published 2020. Accessed July 18, 2020."},{"key":"bibr6-0883073821989164","unstructured":"Subsecretar\u00eda de Salud P\u00fablica, Divisi\u00f3n de Prevenci\u00f3n y Control de enfermedades, MINSAL. Protocolo S\u00edndrome Inflamatorio Multisist\u00e9mico en ni\u00f1os, ni\u00f1as y adolescentes con SARS-CoV-2. https:\/\/www.minsal.cl\/wp-content\/uploads\/2020\/07\/Protocolo-S%C3%ADndrome-inflamatorio050720.pdf. Published July 02, 2020. Accessed July 18, 2020."},{"key":"bibr7-0883073821989164","unstructured":"Equipo COVID-19 Hospital de ni\u00f1os Dr. Exequiel Gonz\u00e1lez Cort\u00e9s. S\u00edndrome Inflamatorio Multisist\u00e9mico Pedi\u00e1trico asociado a COVID-19. Reporte preliminar de 6 casos en una Unidad de Paciente Cr\u00edtico. https:\/\/www.sochipe.cl\/subidos\/links\/SIMCHEGCRepbreve27Jun.pdf. Published June 27, 2020. Accesed July 18, 2020."},{"key":"bibr8-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"bibr9-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009937"},{"key":"bibr10-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-020-05965-1"},{"key":"bibr11-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa240"},{"key":"bibr12-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010034"},{"key":"bibr13-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2687"},{"issue":"20","key":"bibr14-0883073821989164","first-page":"2","volume":"4422","author":"Ellul MA","year":"2020","journal-title":"Lancet Neurol"},{"key":"bibr15-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"bibr16-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"bibr17-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"bibr18-0883073821989164","unstructured":"World Health Organization. Clinical management of COVID-19. https:\/\/www.who.int\/publications\/i\/item\/clinical-management-of-COVID-19. Published May 27, 2020. Accessed July 10, 2020."},{"issue":"17","key":"bibr19-0883073821989164","first-page":"e927","volume":"135","author":"Bolger AF","year":"2017","journal-title":"Circulation"},{"key":"bibr20-0883073821989164","volume-title":"Aids to the Examination of the Peripheral Nervous System","author":"O\u2019Brien M","year":"2010","edition":"5"},{"key":"bibr21-0883073821989164","unstructured":"Johns Hopkins Center for Systems Science and Engineering. COVID-19 Map. https:\/\/coronavirus.jhu.edu\/map.html. Published 2020. Accessed July 25, 2020."},{"key":"bibr22-0883073821989164","unstructured":"Canals M, Canals A, Cuadrado C. Informe COVID-19 Chile Al. 2020. http:\/\/www.saludpublica.uchile.cl\/noticias\/165209\/informe-COVID-19-chile-al-12072020-decimo-segundo-reporte. Published July 12, 2020. Accessed July 30, 2020."},{"key":"bibr23-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12455"},{"key":"bibr24-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2009191"},{"key":"bibr25-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26289"},{"key":"bibr26-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmaa044"},{"issue":"1","key":"bibr27-0883073821989164","first-page":"1","volume":"54","author":"Khalifa M","year":"2020","journal-title":"J Pediatric Infect Dis Soc"},{"key":"bibr28-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30109-5"},{"key":"bibr29-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1097\/NRL.0000000000000291"},{"key":"bibr30-0883073821989164","first-page":"1","author":"Parsons T","year":"2020","journal-title":"J Neurol"},{"key":"bibr31-0883073821989164","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.117001","volume":"416","author":"Abdi S","year":"2020","journal-title":"J Neurol Sci"},{"key":"bibr32-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201187"},{"key":"bibr33-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2065"},{"key":"bibr34-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04469-4"},{"key":"bibr35-0883073821989164","doi-asserted-by":"crossref","unstructured":"Chen R, Wang K, Yu J, Chen Z, Wen C, Xu Z. The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in human and mouse brain. bioRxiv. 2021;11:1860. doi:10.1101\/2020.04.07.030650","DOI":"10.3389\/fneur.2020.573095"},{"key":"bibr36-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05985-9"},{"key":"bibr37-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25807"},{"key":"bibr38-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.03.062"},{"key":"bibr39-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.05.012"},{"key":"bibr40-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25915"},{"key":"bibr41-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.123"},{"key":"bibr42-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16524"},{"key":"bibr43-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2020.05.005"},{"key":"bibr44-0883073821989164","volume":"413","author":"Asadi-Pooya AA","year":"2020","journal-title":"J Neurol Sci"},{"key":"bibr45-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0041-4"},{"key":"bibr46-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.74.19.8913-8921.2000"},{"key":"bibr47-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2019.06.017"},{"key":"bibr48-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.1.e73"},{"key":"bibr49-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009619"},{"key":"bibr50-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-09912-2"},{"key":"bibr51-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2020.e00771"},{"key":"bibr52-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"bibr53-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"bibr54-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009566"},{"key":"bibr55-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30293-0"},{"key":"bibr56-0883073821989164","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323667"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073821989164","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0883073821989164","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0883073821989164","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:40:21Z","timestamp":1777495221000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0883073821989164"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,1]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1177\/0883073821989164"],"URL":"https:\/\/doi.org\/10.1177\/0883073821989164","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,1]]}}}