{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:35:15Z","timestamp":1777804515050,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Few studies have focused on magnetic resonance imaging (MRI) brain findings associated with functional mobility in cerebral palsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine association between MRI findings and Gross Motor Functional Classification System (GMFCS) levels in cerebral palsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Prospective-observational study conducted in Pediatric Neurology Clinic at a public teaching hospital, Northern India. First 3 new cases of cerebral palsy were enrolled on particular neuro-clinic day per week for 1 year. Functional mobility was classified according to GMFCS. Association between MRI findings, cerebral palsy type, and GMFCS levels were evaluated using \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 138 cases (mean age 2.71 [SD = 1.91] years; male [64.5%]) were enrolled. Reported types of cerebral palsy were as follows: spastic quadriplegia (47.8%), spastic diplegia (28.35%), spastic hemiplegia (11.6%), extrapyramidal (6.5%), and ataxic\/hypotonic (5.8%). GMFCS were classified into level 1 (13%), level 2 (7.2%), level 3 (4.3%), level 4 (10.9%), and level 5 (64.5%). Spastic quadriplegia and extrapyramidal cerebral palsy were significantly associated with higher (severe) levels (IV and V), whereas spastic diplegia and hemiplegia were significantly associated with lower (mild) levels (I-III) of GMFCS. MRI features of periventricular white matter injury, deep gray matter injury, basal ganglia and thalamic changes, and superficial gray matter injury were significantly associated with severe levels of GMFCS (V and IV). MRI was normal in 8 children (5 = mild category, 3 = severe category).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Severe cerebral palsy is most often associated with spastic quadriplegia, extrapyramidal cerebral palsy, superficial gray matter lesions, deep gray matter lesions, and periventricular white matter injury. This information is useful for anticipating and addressing the needs of children with cerebral palsy and for prognostication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/0883073821993613","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T06:46:35Z","timestamp":1615531595000},"page":"711-719","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuroradiologic Features Associated With Severe Restriction of Functional Mobility in Children With Cerebral Palsy in North India"],"prefix":"10.1177","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1210-753X","authenticated-orcid":false,"given":"Jayanti","family":"Prabha","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-7051","authenticated-orcid":false,"given":"Areesha","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"},{"name":"Department of Pediatrics, Era\u2019s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrakanta","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neera","family":"Kohli","sequence":"additional","affiliation":[{"name":"Department of Radio-diagnosis, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"bibr1-0883073821993613","doi-asserted-by":"publisher","DOI":"10.1017\/S001216220500112X"},{"key":"bibr2-0883073821993613","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00021"},{"key":"bibr3-0883073821993613","volume-title":"The Epidemiology of the Cerebral Palsies","author":"Ingram TTS","year":"1984"},{"key":"bibr4-0883073821993613","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1542\/peds.95.2.249","volume":"95","author":"Pinto-Martin JA","year":"1995","journal-title":"Pediatrics"},{"key":"bibr5-0883073821993613","unstructured":"International Classification of Impairment, Activity and Participation\u2013ICIDH-2. 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