{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:35:30Z","timestamp":1777804530381,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p>Background: Acute neurological complications from COVID-19 have been reported in both pediatric and adult populations. Chronic symptoms after recovery have been reported in adults and can include neuropsychiatric and sleep symptoms. Persistent symptoms in children with the multisystem inflammatory syndrome in children (MIS-C) have not been studied. Methods: We conducted a single-center retrospective chart review and cross-sectional survey of patients diagnosed with MIS-C. Patients and parents were surveyed on symptoms before the COVID-19 pandemic, upon admission, and 23 weeks (interquartile range 20-26 weeks) after discharge. Age and gender-matched patients requiring intensive care unit (ICU) care for status asthmaticus were surveyed as a control group. Results: In this cohort of 47 patients, 77% reported neurological, 60% psychiatric, and 77% sleep symptoms during hospitalization. Prior to hospitalization, 15% reported neurological, 0% psychiatric, and 7% sleep symptoms. Eighteen (50%) of the 36 patients who had neurological symptoms during hospitalization continued to have symptoms on follow-up (odds ratio [OR]\u2009=\u2009\u221e, p\u2009=\u2009.003]). Similarly, 16 (57%) of 28 patients with psychiatric symptoms reported persistence at follow-up (OR\u2009=\u20095.00; p\u2009=\u2009.02). Fifteen (42%) of the 18 patients reporting sleep disturbance during hospitalization had persistence on follow-up (OR\u2009=\u20091.9; p\u2009=\u2009.49). The aggregate of neurological, psychiatric, and sleep symptoms during admission and at follow-up was significantly higher for MIS-C patients requiring ICU care when compared to the control group ( p\u2009=\u2009.01). Conclusions: In this cohort of patients with MIS-C, a majority of patients reported new-onset neuropsychiatric and sleep symptoms. Almost half of these patients had persistent symptoms on a follow-up survey.<\/jats:p>","DOI":"10.1177\/08830738221075924","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T11:17:46Z","timestamp":1643023066000},"page":"426-433","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Patients Diagnosed with Multisystem Inflammatory Syndrome in Children Have Persistent Neurologic, Sleep, and Psychiatric Symptoms After Hospitalization"],"prefix":"10.1177","volume":"37","author":[{"given":"Stephanie","family":"Enner","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Cohen Children\u2019s Medical Center, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yash D.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Cohen Children\u2019s Medical Center, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaqil","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Cohen Children\u2019s Medical Center, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E.","family":"Cerise","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Feinstein Institute for Medical Research, Northwell Health Manhasset, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Esposito","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorry","family":"Rubin","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, NY, USA"},{"name":"Division of Pediatric Infectious Disease, Department of Pediatrics, Cohen Children\u2019s Medical Center, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anupama","family":"Subramony","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, NY, USA"},{"name":"Department of Pediatrics, Cohen Children\u2019s Medical Center, Northwell Health, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-1115","authenticated-orcid":false,"given":"Sanjeev","family":"Kothare","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology, Department of Pediatrics, Cohen Children\u2019s Medical Center, NY, USA"},{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"bibr1-08830738221075924","volume":"145","author":"Dong Y","journal-title":"Pediatrics."},{"key":"bibr2-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-003186"},{"key":"bibr3-08830738221075924","unstructured":"United States, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases.\n                      COVID-19: information for pediatric healthcare providers\n                      , CDC.gov, 2020. https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/pediatric-hcp.html."},{"key":"bibr4-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0504"},{"key":"bibr5-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1127"},{"key":"bibr6-08830738221075924","unstructured":"\u201cMultisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19).\u201d\n                      Centers for Disease Control and Prevention\n                      , CDC Health Alert Network, 27 March 2020, https:\/\/emergency.cdc.gov\/han\/2020\/han00432.asp."},{"key":"bibr7-08830738221075924","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6932e2"},{"key":"bibr8-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.06.044"},{"key":"bibr9-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-4642(20)30314-X"},{"key":"bibr10-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2020.06.015"},{"key":"bibr11-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.09.015"},{"key":"bibr12-08830738221075924","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2431-5-14","volume":"5","author":"Carlton-Conway D","year":"2005","journal-title":"BMC Pediatr"},{"key":"bibr13-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.5.463"},{"key":"bibr14-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(21)00084-5"},{"key":"bibr15-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.04.027"},{"key":"bibr16-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.384"},{"key":"bibr17-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1177\/0883073817720340"},{"key":"bibr18-08830738221075924","unstructured":"United States, Centers for Disease Control and Prevention, National Notifiable Diseases Surveillance System (NNDSS).\n                      Coronavirus Disease 2019 (COVID-19) 2020 Interim Case Definition\n                      , Approved April 5, 2020, CDC.gov, 2020."},{"key":"bibr19-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"bibr20-08830738221075924","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2687"},{"key":"bibr21-08830738221075924","volume":"19","author":"Malas N","year":"2017","journal-title":"Curr Psychiatry Rep."}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738221075924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08830738221075924","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738221075924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:40:26Z","timestamp":1777495226000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738221075924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1177\/08830738221075924"],"URL":"https:\/\/doi.org\/10.1177\/08830738221075924","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]}}}