{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:59:58Z","timestamp":1792299598893,"version":"4.4.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:p>Background: Subacute sclerosing panencephalitis is a progressive devastating condition due to persistence of mutant measles virus, affecting children and adolescents, characterised by myoclonus, seizures, and neuropsychiatric issues. Movement disorders apart from myoclonus are reportedly uncommon. We aimed to describe frequency and proportion of movement disorders among children with subacute sclerosing panencephalitis, hypothesizing that these occur more frequently than previously reported. Methods: In this cross-sectional study, we enrolled children with subacute sclerosing panencephalitis between 1 month and 18 years of age who fulfilled the diagnosis of subacute sclerosing panencephalitis as per modified Dyken criteria, and examined them for movement disorders. We also assessed their clinical profile and disease severity via Jabbour staging and modified Rankin Scale score. We compared demographic, clinical, and laboratory features of children with and without movement disorders. Results: We enrolled 50 children (36 males; 72%) (age range 1.5-14 years). Of these, 28 (56%) had movement disorders. Among movement disorders, the most frequent was myoclonus (92%), followed by ataxia (9; 18%), chorea-athetosis (7; 14%), dystonia (6; 12%), tremor (4; 8%), repetitive behavior (4; 8%), and parkinsonism (3; 6%). Movement disorders were the presenting feature of subacute sclerosing panencephalitis among 7 children. There were no significant differences in clinical or laboratory features among children with and without movement disorders. Conclusions: Movement disorders were frequent in subacute sclerosing panencephalitis. Hyperkinetic disorders were dominant. Dystonia and chorea-athetosis occurred more commonly among nonmyoclonus movement disorders. Movement disorders may manifest even in earlier stages of subacute sclerosing panencephalitis and may be the heralding feature. Recognition of these features is important to plan management and reduce morbidity.<\/jats:p>","DOI":"10.1177\/08830738221085158","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T11:16:03Z","timestamp":1646824563000},"page":"491-496","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Spectrum of Movement Disorders Among Children With Subacute Sclerosing Panencephalitis: A Cross-Sectional Study"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-3370","authenticated-orcid":false,"given":"Divyani","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Neurology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6482-2175","authenticated-orcid":false,"given":"Vanshika","family":"Kakkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neurology Division), Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashna","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neurology Division), Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipti","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neurology Division), Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Abbey","sequence":"additional","affiliation":[{"name":"Department of Radiology, Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Pemde","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neurology Division), Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3184-464X","authenticated-orcid":false,"given":"Sharmila B.","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neurology Division), Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-3306","authenticated-orcid":false,"given":"Suvasini","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (Neurology Division), Lady Hardinge Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"bibr1-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2058"},{"key":"bibr2-08830738221085158","doi-asserted-by":"publisher","DOI":"10.2147\/PHMT.S126293"},{"key":"bibr3-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800054637"},{"key":"bibr4-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000932"},{"key":"bibr5-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmu050"},{"key":"bibr6-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2021.07.006"},{"key":"bibr7-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2019.10.035"},{"issue":"3","key":"bibr8-08830738221085158","first-page":"161","volume":"41","author":"Sonia M","year":"2009","journal-title":"J Commun Dis"},{"issue":"4","key":"bibr9-08830738221085158","first-page":"235","volume":"49","author":"Mishra B","year":"2005","journal-title":"Indian J Public Health."},{"key":"bibr10-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1177\/0883073813520498"},{"key":"bibr11-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-233397"},{"issue":"5","key":"bibr12-08830738221085158","first-page":"441","volume":"55","author":"Goswami JN","year":"2018","journal-title":"Indian Pediatr"},{"key":"bibr13-08830738221085158","unstructured":"Dash D, Tripathi M, Singh R. Movement disorders as a clinical feature of subacute sclerosing pan encephalitis: expansion of phenotypic spectrum. MDS Abstracts. Accessed September 29, 2020. https:\/\/www.mdsabstracts.org\/abstract\/movement-disorders-as-a-clinical-feature-of-subacute-sclerosing-pan-encephalitis-expansion-of-phenotypic-spectrum\/"},{"key":"bibr14-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28323"},{"issue":"4","key":"bibr15-08830738221085158","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4103\/aian.AIAN_249_18","volume":"22","author":"Kamate M","year":"2019","journal-title":"Ann Indian Acad Neurol."},{"key":"bibr16-08830738221085158","author":"Misra AK","journal-title":"Neurol Asia."},{"key":"bibr17-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.4092"},{"key":"bibr18-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001161"},{"key":"bibr19-08830738221085158","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.152678"},{"key":"bibr20-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1177\/1941874418776902"},{"key":"bibr21-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2015.02.008"},{"issue":"11","key":"bibr22-08830738221085158","first-page":"1067","volume":"50","author":"Dey PK","year":"2013","journal-title":"Indian Pediatr"},{"key":"bibr23-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2016.02.005"},{"key":"bibr24-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)31062-4"},{"key":"bibr25-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1177\/003693305700200504"},{"issue":"2","key":"bibr26-08830738221085158","first-page":"73","volume":"2","author":"Khadilkar SV","year":"2004","journal-title":"J Pediatr Neurol."},{"key":"bibr27-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2005.085829"},{"key":"bibr28-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0b013e318278bf06"},{"key":"bibr29-08830738221085158","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2011.02.027"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738221085158","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08830738221085158","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738221085158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:40:29Z","timestamp":1777495229000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738221085158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1177\/08830738221085158"],"URL":"https:\/\/doi.org\/10.1177\/08830738221085158","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]}}}