{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:48:32Z","timestamp":1783475312517,"version":"3.55.0"},"reference-count":40,"publisher":"SAGE Publications","issue":"10-11","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n                    Background:There is still a need for more studies to evaluate the role of vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    in pediatric migraine prophylaxis. Objectives: We aimed to evaluate the effects and safety of vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation to topiramate on pediatric migraine. Methods: A double-blinded prospective clinical trial was conducted on 5- to 14-year-old children with migraine. They were randomly assigned in a 1:1 ratio into 2 groups, one with vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation (the supplementation group) and the other without vitamin D supplementation (the placebo group). The supplementation group received topiramate plus one 5000-IU dose of vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    daily for 4 months. The placebo group received topiramate with a placebo capsule without any effective substances. The primary outcomes were a monthly frequency of headache attacks, a good response to intervention, and reduction in migraine severity, duration, and disability before and after treatment. Fifty-six children completed the trial. Vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation to topiramate was more effective than the placebo group in the reduction of monthly frequency (6231.31 vs 9792.24 times, P\u2009=\u2009.01) and disability score for migraines (17 566.43 vs 25 187.65, P\u2009=\u2009.04). A good response was observed in 76.13% of patients in the vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation group and 53.5% of patients in the placebo group, and vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation was significantly more effective than placebo ( P\u2009=\u2009.01). Side effects were observed in 13.3% and 20% of the intervention group and placebo groups, respectively, P\u2009=\u2009.5. Conclusion: Vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    supplementation in pediatric migraine prophylaxis could be a well-tolerated, safe, and effective strategy.\n                  <\/jats:p>","DOI":"10.1177\/08830738221092882","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T01:55:01Z","timestamp":1655949301000},"page":"833-839","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["The Impact of Vitamin D\n                    <sub>3<\/sub>\n                    Supplementation to Topiramate Therapy on Pediatric Migraine Prophylaxis"],"prefix":"10.1177","volume":"37","author":[{"given":"Moustafa","family":"Kotb Elmala","sequence":"first","affiliation":[{"name":"Pediatric Department, Nizwa Hospital, Nizwa, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany Abdelaziz","family":"Suliman","sequence":"additional","affiliation":[{"name":"Pediatric Department, Benha University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf Hamed","family":"Al-shokary","sequence":"additional","affiliation":[{"name":"Pediatric Department, Benha University, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa Obada","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Pediatric Department, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa M.","family":"Kamal","sequence":"additional","affiliation":[{"name":"Pediatric Department, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-3179","authenticated-orcid":false,"given":"Hatem Hamed","family":"Elshorbagy","sequence":"additional","affiliation":[{"name":"Pediatric Department, Menoufia University, Shebeen Elkom, Egypt"},{"name":"Pediatric Department, Alhada and Taif Armed Forces Hospitals, Taif, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled Amin","family":"Nasef","sequence":"additional","affiliation":[{"name":"Pediatric Department, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Gamal","family":"El Din Fathallah","sequence":"additional","affiliation":[{"name":"Pediatric Department, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"bibr1-08830738221092882","doi-asserted-by":"publisher","DOI":"10.1177\/0333102416660533"},{"key":"bibr2-08830738221092882","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2008.11.003"},{"key":"bibr3-08830738221092882","first-page":"2866","volume-title":"Nelson Textbook of Pediatrics","author":"Hershey 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