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Although major gains have been made in understanding the pathophysiology of migraine in adults in recent years, equivalent research on migraine in pediatric patients continues to lag behind. In this review, we will describe the current state of migraine research in pediatric patients with regard to presentation and frequency of prodromal and postdromal symptoms, ictal and interictal calcitonin gene-related peptide elevation, and evidence for cortical spreading depression, thus covering all phases of migraine, and discuss how the findings seen here may relate to possible underlying pathophysiological mechanisms of migraine. We aim to elucidate possible differences between migraine in children and adults, and the need for further research specific to pediatric patients with migraine in order to improve treatment in this patient group.<\/jats:p>","DOI":"10.1177\/08830738221100888","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T01:33:48Z","timestamp":1653356028000},"page":"642-651","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Migraine Pathophysiology in Children and Adolescents: A Review of the Literature"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-6103","authenticated-orcid":false,"given":"Astrid","family":"F\u00f8rland-Schill","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Herlev Hospital, Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-5198","authenticated-orcid":false,"given":"Amalie","family":"Berring-Uldum","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Herlev Hospital, Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-1865","authenticated-orcid":false,"given":"Nanette Mol","family":"Debes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Herlev Hospital, Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"bibr1-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"bibr2-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1177\/0333102409355601"},{"key":"bibr3-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03793.x"},{"key":"bibr4-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"bibr5-08830738221100888","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.82.3.364"},{"key":"bibr6-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/head.12251"},{"key":"bibr7-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6957.765"},{"key":"bibr8-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.1996.3602077.x"},{"key":"bibr9-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"bibr10-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/head.12150"},{"key":"bibr11-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01195.x"},{"key":"bibr12-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1177\/0333102415620251"},{"key":"bibr13-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000052998.58526.A9"},{"key":"bibr14-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2004.04168.x"},{"key":"bibr15-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2006.01157.x"},{"key":"bibr16-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000310"},{"key":"bibr17-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002789"},{"key":"bibr18-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2010.01817.x"},{"key":"bibr19-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1991.1105229.x"},{"key":"bibr20-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01026.x"},{"key":"bibr21-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.2000.00030.x"},{"key":"bibr22-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6320.944"},{"key":"bibr23-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1984.0402085.x"},{"key":"bibr24-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008095"},{"key":"bibr25-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008105"},{"key":"bibr26-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/head.12105"},{"key":"bibr27-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610384"},{"key":"bibr28-08830738221100888","doi-asserted-by":"publisher","DOI":"10.1111\/head.13337"},{"key":"bibr29-08830738221100888","doi-asserted-by":"crossref","unstructured":"Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E; Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. 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