{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:37:15Z","timestamp":1777804635625,"version":"3.51.4"},"reference-count":55,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate use of a standardized, 3-tiered, seizure burden-based protocol for treatment of all electroencephalography (EEG)-confirmed seizures in a level IV neonatal intensive care unit (NICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>All infants admitted to the NICU with EEG-confirmed seizures over a 25-month period were enrolled in the study. We compared short-term outcomes before and after implementation of a standardized, 3-tiered protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 107 infants were enrolled in the study. Use of midazolam infusions was reduced by 53.7% ( p \u2009=\u20090.02). Midazolam infusion duration increased from 4 to 7.5 days ( p = 0.003); however, when excluding 3 outliers, there was no significant difference between groups (\u00ad p \u2009= 0.67). Duration of EEG monitoring decreased from 5 to 3 days ( p \u2009=\u20090.005). Hospital length of stay was unchanged.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implementation of a standardized, 3-tiered protocol for treatment of neonatal seizures improved short-term outcomes. Although not measured directly, reductions in EEG duration and midazolam use are promising indicators of overall seizure burden. More research is needed to evaluate impact on long-term neurodevelopmental outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738231164704","type":"journal-article","created":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T02:20:06Z","timestamp":1680661206000},"page":"142-152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["A Standardized, 3-Tiered, Seizure Burden\u2013Based Protocol for the Treatment of Neonatal Seizures"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3442-7382","authenticated-orcid":false,"given":"Ashley A.","family":"Moeller","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei R.","family":"Stefanescu","sequence":"additional","affiliation":[{"name":"Tulane University School of Public Health and 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