{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:35:34Z","timestamp":1781080534500,"version":"3.54.1"},"reference-count":19,"publisher":"SAGE Publications","issue":"10-12","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>It is well established that extreme prematurity can be associated with cerebellar lesions potentially affecting the neurologic prognosis. One of the commonly observed lesions in these cases is pontocerebellar hypoplasia resulting from prematurity, which can pose challenges in distinguishing it from genetically caused pontocerebellar hypoplasia. This confusion leads to unacceptable and prolonged diagnostic ambiguity for families as well as difficulties in genetic counseling. Therefore, it is crucial to identify the clinical and neuroradiologic features allowing to differentiate between acquired and genetic forms of pontocerebellar hypoplasia in order to guide clinical practices and improve patient care. In this regard, we report in the present manuscript the clinical, developmental, and radiologic characteristics of 19 very premature children (gestational age &lt;28 weeks, now aged 3-14 years) with cerebellar lesions and discuss the causal mechanisms. Our findings support the notion that a combination of specific clinical and radiologic criteria is essential in distinguishing between acquired and genetic forms of pontocerebellar hypoplasia.<\/jats:p>","DOI":"10.1177\/08830738231201926","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T02:36:51Z","timestamp":1695263811000},"page":"622-630","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Differentiating Genetic Forms of Pontocerebellar Hypoplasia From Acquired Lesions Resembling Pontocerebellar Hypoplasia: Clinical, Neurodevelopmental, and Imaging Insight From 19 Extremely Premature Patients"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4291-604X","authenticated-orcid":false,"given":"Audrey","family":"Riquet","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Saint Vincent de Paul Hospital, GHICL, Catholic University of Lille, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Quesque","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, Centre de Recherche en Neurosciences de Lyon CRNL U1028 UMR5292, Trajectoires, Universit\u00e9 Claude Bernard Lyon 1, Bron, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Laure","family":"Charkaluk","sequence":"additional","affiliation":[{"name":"Department of Neonatalogy, Saint Vincent de Paul Hospital, GHICL, Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Desnoulez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CH Arras, Arras, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Neut","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, CH Boulogne, Boulogne-sur-Mer, 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