{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:39:14Z","timestamp":1777804754383,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"5-6","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To document the association of CAD-related disorder (EIEE-50) with cortical visual impairment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observations<\/jats:title>\n                    <jats:p>An 8-month-old Caucasian boy with whole genome sequencing confirming 2 variants in the gene CAD, who presented with severe seizures, microcephaly, hyperreflexia, hypotonia, anemia, and severe cortical visual impairment. Magnetic resonance imaging (MRI) of the brain noted thickened cortical gray matter along the right calcarine fissure as well as changes suggesting malformation of cortical development. Empiric uridine monophosphate supplementation has significantly improved seizure activity, hypotonia, and development and has led to resolution of anemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Importance<\/jats:title>\n                    <jats:p>CAD-related disorder is treatable and may affect visual cortical development causing severe secondary cortical visual impairment, a newly described clinical manifestation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738241255247","type":"journal-article","created":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T04:34:30Z","timestamp":1716352470000},"page":"218-221","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>CAD<\/i>\n                    -Related Disorder (EIEE-50) in an Infant With Cortical Visual Impairment"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7162-4005","authenticated-orcid":false,"given":"Sarah","family":"Thurman","sequence":"first","affiliation":[{"name":"Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Callie","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Guerin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralitza","family":"Gavrilova","sequence":"additional","affiliation":[{"name":"Department of Clinical Genomics\/Department of Neurology, Mayo Clinic, Rochester MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Brodsky","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,5,22]]},"reference":[{"key":"bibr1-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv057"},{"key":"bibr2-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgmr.2021.100835"},{"key":"bibr3-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww300"},{"key":"bibr4-08830738241255247","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00064"},{"key":"bibr5-08830738241255247","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.608737"},{"key":"bibr6-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"bibr7-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0933-z"},{"key":"bibr8-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39968-4"},{"key":"bibr9-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.001345"},{"key":"bibr10-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00849-1"},{"key":"bibr11-08830738241255247","doi-asserted-by":"publisher","DOI":"10.1177\/10738584211009149"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738241255247","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08830738241255247","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738241255247","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:41:07Z","timestamp":1777495267000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738241255247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":11,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1177\/08830738241255247"],"URL":"https:\/\/doi.org\/10.1177\/08830738241255247","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]}}}