{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:39:45Z","timestamp":1777804785791,"version":"3.51.4"},"reference-count":36,"publisher":"SAGE Publications","issue":"9-10","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["K12EY015398"],"award-info":[{"award-number":["K12EY015398"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Describe the clinical characteristics, treatment strategies, and outcome data of children with papilledema associated with Lyme disease at a large tertiary care pediatric hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study of children 1-18 years old who received care at our institution between 1995 and 2019 with concurrent diagnoses of papilledema and Lyme disease. Data were abstracted from records and prospective family surveys.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 44 children included (median age 9.7 years), 66% (29\/44) had additional cranial neuropathies, and 78% (32\/41) had cerebrospinal fluid pleocytosis. All children were treated with antibiotics (39% oral, 55% intravenous, 7% both); 61% (27\/44) were also treated with oral acetazolamide. Symptoms fully resolved in 86% (30\/35) of children with follow-up data. Proportion recovered did not significantly differ by antibiotic administration route or presence\/absence of cerebrospinal fluid pleocytosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Papilledema in Lyme disease may occur with or without cerebrospinal fluid pleocytosis. Most children recover without residual deficits following treatment, although exceptions exist.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738241273376","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T05:03:10Z","timestamp":1725253390000},"page":"334-342","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Lyme Disease and Papilledema: A Retrospective Study on Clinical Characteristics and Outcomes"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1070-5237","authenticated-orcid":false,"given":"Joseph","family":"Vithayathil","sequence":"first","affiliation":[{"name":"Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2624-9974","authenticated-orcid":false,"given":"Akash","family":"Virupakshaiah","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuroimmunology and Glial Biology, University of California, San Francisco, Los Angeles, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev K.","family":"Swami","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Children's Hospital of Philadelphia, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Avery","sequence":"additional","affiliation":[{"name":"Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant T.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Division of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"McGuire","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA"},{"name":"Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"},{"name":"Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"bibr1-08830738241273376","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6622a1"},{"key":"bibr2-08830738241273376","doi-asserted-by":"publisher","DOI":"10.3201\/eid2109.150417"},{"key":"bibr3-08830738241273376","unstructured":"Centers for Disease Control and Prevention. 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