{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:08:45Z","timestamp":1793909325422,"version":"4.8.0"},"reference-count":18,"publisher":"SAGE Publications","issue":"11-12","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Here we describe a pediatric patient with febrile infection\u2013related epilepsy syndrome with a good functional and neurologic outcome after treatment with early and aggressive cytokine-directed immunomodulatory therapy and a seizure management strategy that intentionally avoided a barbiturate coma. A 5-year-old previously healthy male presented with staring, behavioral arrest, and encephalopathy evolving to super-refractory status epilepticus. He had had onset of fever 5 days prior. He was treated with early and aggressive immunomodulatory therapy targeted to his evolving cytokine profile. He was also treated with the ketogenic diet, antiseizure medications, and continuous anesthetic infusions. Pentobarbital was purposely avoided. Now, 2\u00bd years later, he attends mainstream school, has attention-deficit hyperactivity disorder (ADHD), mild neurocognitive impairment, and well-controlled epilepsy. By using cytokine-directed immunotherapy and avoiding a barbiturate coma, we were able to successfully treat a pediatric patient with febrile infection-related epilepsy syndrome and achieve a good outcome.<\/jats:p>","DOI":"10.1177\/08830738241273448","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T11:00:55Z","timestamp":1724842855000},"page":"440-445","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Successful Management of Febrile Infection\u2013Related Epilepsy Syndrome Using Cytokine-Directed Therapy"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-8479","authenticated-orcid":false,"given":"Dana B.","family":"Harrar","sequence":"first","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyse","family":"Genser","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mejdi","family":"Najjar","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Davies","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, Children's National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Sule","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Children's National Hospital, Washington, DC, 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Wells","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"},{"name":"Brain Tumor Institute, Children's National Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"bibr1-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1111\/epi.16950"},{"key":"bibr2-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03250.x"},{"key":"bibr3-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2021.108413"},{"key":"bibr4-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12447"},{"key":"bibr5-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17391"},{"key":"bibr6-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17397"},{"key":"bibr7-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03230.x"},{"key":"bibr8-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25439"},{"key":"bibr9-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24806"},{"key":"bibr10-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25374"},{"key":"bibr11-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14524"},{"key":"bibr12-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207068"},{"key":"bibr13-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2018.12.007"},{"key":"bibr14-08830738241273448","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.643105"},{"key":"bibr15-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14480"},{"key":"bibr16-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200889"},{"key":"bibr17-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-018-0513-0"},{"key":"bibr18-08830738241273448","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811424941"}],"container-title":["Journal 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