{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:04:15Z","timestamp":1790633055401,"version":"4.1.0"},"reference-count":30,"publisher":"SAGE Publications","issue":"13-14","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Objective: The study aimed to investigate the clinical outcomes of fetuses diagnosed with isolated mega cisterna magna in utero. Methods: A multicenter retrospective cohort study was conducted across 18 university hospitals from 2010 to 2019. Cases diagnosed with isolated mega cisterna magna, defined as a cisterna magna &gt;10 mm with a normal cerebellar vermis and no cystic dilation of the fourth ventricle, were included. Cases with other central nervous system (CNS) anomalies, extra\u2013central nervous system anomalies, chromosomal abnormalities, or congenital infections were excluded. Maternal demographics, prenatal findings, delivery outcomes, and postnatal outcomes were analyzed. Results: The mean gestational age at initial diagnosis was 28.6\u2009\u00b1\u20093.9 weeks, and the mean anteroposterior diameter of the cisterna magna was 12.5\u2009\u00b1\u20093.2 mm. Of the 71 cases initially assessed, 48 (67.6%) showed self-regression in utero. Postnatally, 13 cases (18.3%) had persistent isolated mega cisterna magna, whereas 10 cases (14.1%) were diagnosed with other central nervous system anomalies. Among the persistent isolated mega cisterna magna cases, one child exhibited delayed neurodevelopment. There was a higher incidence of isolated mega cisterna magna in male fetuses, which exhibited a significantly larger mean cisterna magna diameter compared with female fetuses ( P\u2009=\u2009.045). Conclusion: Male fetuses exhibited a higher incidence of isolated mega cisterna magna compared with female fetuses and had larger anteroposterior diameters of the cisterna magna. The study demonstrated favorable neurodevelopmental outcomes associated with isolated mega cisterna magna, with self-regression observed in two-thirds of the cases. However, consecutive prenatal and postnatal evaluations for additional central nervous system or extra\u2013central nervous system malformations need to be performed, considering the differences between prenatal and postnatal diagnoses.<\/jats:p>","DOI":"10.1177\/08830738241282037","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T05:02:27Z","timestamp":1727931747000},"page":"481-486","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Prenatal Diagnosis and Clinical Outcomes of Isolated Mega Cisterna Magna"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0119-3396","authenticated-orcid":false,"given":"Oyoung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Yeouido St. Mary`s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subeen","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mi","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea"},{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Joo","family":"Seol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kyung Hee University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Gon","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keimyung University College of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Hoon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Yan","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University Health System, Seodaemun-gu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hee","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Ran","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Inha University College of Medicine, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Biomedical Research Institute, Pusan National University College of Medicine, Busan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Kyungpook National University, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Eun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecolgy, Kangnam Sacred Heart Hospital, Hallym University Medical Center, Hallym University College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Sung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Sung","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Kwan","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Seoul National University Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Sun","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of 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