{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:35:33Z","timestamp":1793144133713,"version":"4.5.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"\n Introduction:<\/jats:bold>\n Vitamin B\n 12<\/jats:sub>\n deficiency is a well-known cause of neurologic symptoms, prompting routine measurement in patients with neurologic conditions. However, elevated B\n 12<\/jats:sub>\n levels are also observed in some cases. Recent studies suggest a potential link between high B\n 12<\/jats:sub>\n levels and neurologic or neurodevelopmental disorders. This study aims to evaluate vitamin B\n 12<\/jats:sub>\n levels in children with neurologic disorders compared with those in general pediatric populations.\n Materials and Methods:<\/jats:bold>\n This single-center retrospective study analyzed pediatric patients\u2019 vitamin B\n 12<\/jats:sub>\n levels between 2000 and 2023. Exclusion criteria included incomplete data and vitamin supplementation. Patients were grouped based on B\n 12<\/jats:sub>\n levels (<200\u2005pg\/mL, 201-660\u2005pg\/mL, 661-1000\u2005pg\/mL, >\u20091000\u2005pg\/mL). Age, gender, and diagnoses were assessed, focusing on patients with elevated B\n 12<\/jats:sub>\n levels (>660\u2005pg\/mL) in the neurology clinic. Vitamin B\n 12<\/jats:sub>\n levels were measured using Roche Cobas e 601 analyzers.\n Results:<\/jats:bold>\n Over 3 years, 4142 pediatric clinic and 2638 pediatric neurology patients were reviewed. Elevated B\n 12<\/jats:sub>\n levels were more frequent in the neurology clinic. Patients with elevated B\n 12<\/jats:sub>\n levels (n\u2009=\u2009338) had a mean age of 8.67 months and a mean B\n 12<\/jats:sub>\n level of 894.7\u2005pg\/mL. Of 137 patients with follow-up B\n 12<\/jats:sub>\n measurements, 40.1% normalized, while 17.5% remained > 1000\u2005pg\/mL. The most common diagnosis in patients with persistently high B\n 12<\/jats:sub>\n levels was epilepsy, followed by prematurity, cerebral palsy, autism, intellectual disability, and language delay.\n Conclusions:<\/jats:bold>\n Elevated vitamin B\n 12<\/jats:sub>\n levels were associated with pediatric neurologic disorders, particularly epilepsy. Further research is needed to clarify the mechanisms and clinical implications of this finding.\n <\/jats:p>","DOI":"10.1177\/08830738251319056","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T13:35:25Z","timestamp":1741095325000},"page":"433-438","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Neurologic Disease and Vitamin B\n 12<\/sub>\n Levels in Children"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-2843","authenticated-orcid":false,"given":"Bet\u00fcl","family":"Diler Durgut","sequence":"first","affiliation":[{"name":"Giresun University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2012-0545"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct051"},{"issue":"12","key":"e_1_3_2_4_2","first-page":"1","article-title":"Should we worry about elevated B12 levels in children?","volume":"7","author":"Butala S","year":"2021","unstructured":"Butala S, Teresczuk M, Malay S, Pateva I. Should we worry about elevated B12 levels in children? Clin Res Trials. 2021;7(12):1\u20135.","journal-title":"Clin Res Trials"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900855RRR"},{"issue":"2","key":"e_1_3_2_6_2","first-page":"1","article-title":"Why are vitamin B12 levels high in children with cerebral palsy?","volume":"3","author":"Ayd\u0131n H","year":"2023","unstructured":"Ayd\u0131n H, Bucak IH, Tastan S. Why are vitamin B12 levels high in children with cerebral palsy? Hippocrates Med J. 2023;3(2):1\u20138.","journal-title":"Hippocrates Med J"},{"issue":"3","key":"e_1_3_2_7_2","article-title":"The effect of high-dose methyl vitamin B12 therapy on epileptogenesis in rats: an in vivo study","volume":"15","author":"Fakhroo A","year":"2023","unstructured":"Fakhroo A, Al-Hammadi M, Fakhroo L, et al. The effect of high-dose methyl vitamin B12 therapy on epileptogenesis in rats: an in vivo study. Cureus. 2023;15(3):e35929. doi: https:\/\/doi.org\/10.7759\/cureus.35929. PMID: 37050999; PMCID: PMC10085463.","journal-title":"Cureus"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.55782\/ane-2015-2028"},{"key":"e_1_3_2_9_2","article-title":"Vitamin B12 enhances GABA content but reduces glutamate content in the rat suprachiasmatic nucleus","volume":"273","author":"Ikeda M","year":"1997","unstructured":"Ikeda M, Azuma S, Inou\u00e9 S. Vitamin B12 enhances GABA content but reduces glutamate content in the rat suprachiasmatic nucleus. Am J Physiol. 1997;273:R359\u2013R363. https:\/\/doi.org\/10.1152\/ajpregu.1997.273.1.R359","journal-title":"Am J Physiol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03252-0"},{"issue":"1","key":"e_1_3_2_11_2","first-page":"004188","article-title":"Macro-Vitamin B12 as cause of falsely elevated cobalamin levels","volume":"11","author":"Belkhouribchia J","year":"2023","unstructured":"Belkhouribchia J. Macro-Vitamin B12 as cause of falsely elevated cobalamin levels. Eur J Case Rep Intern Med. 2023;11(1):004188. doi: https:\/\/doi.org\/10.12890\/2023_004188. 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