{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:38:04Z","timestamp":1777941484056,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To define the clinical presentations, visual outcomes, and treatment practices for pediatric optic neuritis at a tertiary children's hospital in the United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review was conducted for patients aged 0-16 years diagnosed with optic neuritis over a 10-year period. Demographic and clinical data were retrieved from electronic and archived medical records. Follow-up assessments were completed at intervals of 2 weeks, 3 months, 6 months, 1 year, and 3 years, with a minimum follow-up of 2 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen patients experienced their first optic neuritis episode, with 81% presenting unilaterally and 19% bilaterally. All patients reported visual loss or blurring; headache, eye pain, and dizziness were also common. Poor visual acuity (&gt;0.3 logMAR) was noted in 78% of eyes at presentation. Relative afferent pupillary defects were observed in 85% of unilateral cases, and initial color vision deficits were present in 64%. Disc swelling affected 46% of unilateral cases. Treatments varied, with all bilateral cases receiving intravenous methylprednisolone followed by oral steroids; 62% of unilateral cases received similar treatment. No optic neuritis recurrences were noted within the study period. Final visual outcomes did not significantly differ across myelin-oligodendrocyte glycoprotein\u2013positive, multiple sclerosis\u2013associated, and isolated pediatric optic neuritis groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with pediatric optic neuritis present with initial poor visual acuity, from which the majority substantially improve within 3 months, though significant further recovery may occur up to 1 year post-presentation. Myelin-oligodendrocyte glycoprotein\u2013positive disease appears to be a significant cause of pediatric optic neuritis. Treatment practices show significant variability; however, the trend for intravenous corticosteroid use continues to predominate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738251326959","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:04:16Z","timestamp":1744279456000},"page":"455-462","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment and Outcomes of Pediatric Optic Neuritis in a Tertiary Children\u2019s Hospital in the United Kingdom: A 10-Year Retrospective Review"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-6740","authenticated-orcid":false,"given":"Haider","family":"Shah","sequence":"first","affiliation":[{"name":"Alder Hey Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"McNamee","sequence":"additional","affiliation":[{"name":"Alder Hey Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navid","family":"Hakim","sequence":"additional","affiliation":[{"name":"Alder Hey Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Gonzalez-Martin","sequence":"additional","affiliation":[{"name":"Alder Hey Children\u2019s Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000607"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000339482.84392.bd"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822facdd"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517713669"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-012-6441-6"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2014.05.036"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000360"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2016-309978"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202273260901"},{"issue":"4","key":"e_1_3_2_11_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2019.09.046","article-title":"The Optic Neuritis Treatment Trial","volume":"127","author":"Newman JN","year":"2020","unstructured":"Newman JN. 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