{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:52:06Z","timestamp":1781815926127,"version":"3.54.5"},"reference-count":38,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to determine the clinical features of hemiplegic cerebral palsy associated with perinatal arterial ischemic stroke or periventricular venous infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied children with hemiplegic cerebral palsy enrolled at 9 rehabilitation centers across Ontario. We compared children with underlying perinatal arterial ischemic stroke or periventricular venous infarction on clinically acquired brain imaging. Analysis also included prenatal (maternal, prenatal\/gestational) and perinatal (obstetrical, neonatal) clinical features collected from birth records and standardized parent interviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 144 children with hemiplegic cerebral palsy (62% male) included 95 with perinatal arterial ischemic stroke and 49 with periventricular venous infarction. In this cohort of children with hemiplegic cerebral palsy, we found neonatal systemic thrombosis (ie, blood clots in the body) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.05), emergency cesarean section (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.05), and neonatal seizures (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.01) to be clinical features associated with hemiplegic cerebral palsy in children with perinatal arterial ischemic stroke more often than periventricular venous infarction. Preterm delivery rates were similar for perinatal arterial ischemic stroke and periventricular venous infarction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We determined clinical features associated with the 2 most typical forms of focal ischemic brain injury in children with hemiplegic cerebral palsy, including mode of delivery emergency cesarean section, neonatal seizures and systemic thrombosis. These findings provide further insight and support for existing findings about focal brain injury patterns leading to hemiplegic cerebral palsy in children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738251327615","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T09:48:46Z","timestamp":1744278526000},"page":"535-542","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Hemiplegic Cerebral Palsy: Clinical Features Associated With Arterial Ischemic Stroke or Periventricular Venous Infarction"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-8735","authenticated-orcid":false,"given":"Trish","family":"Domi","sequence":"first","affiliation":[{"name":"Hospital for Sick Children Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darcy","family":"Fehlings","sequence":"additional","affiliation":[{"name":"Holland Bloorview Kids Rehabilitation Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Krishnan","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manohar","family":"Shroff","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matylda","family":"Machnowska","sequence":"additional","affiliation":[{"name":"Sunnybrook Health Sciences Centre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Robertson","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomazulu","family":"Dlamini","sequence":"additional","affiliation":[{"name":"Hospital for Sick Children Research Institute"},{"name":"The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"deVeber","sequence":"additional","affiliation":[{"name":"The Hospital for Sick Children"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of Cerebral Palsy Integrated Neuroscience Discovery Network (CP-NET) Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638280500158422"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12331"},{"key":"e_1_3_3_4_2","first-page":"7","article-title":"Brain lesions in children with unilateral spastic cerebral palsy","volume":"71","author":"Hadzagic-Catibusic F","year":"2017","unstructured":"Hadzagic-Catibusic F, Avdagic E, Zubcevic S, Uzicanin S. 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