{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:34:45Z","timestamp":1793932485302,"version":"4.8.0"},"reference-count":23,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>Rett syndrome is an X-linked dominant neurodevelopmental disorder characterized by cognitive and communicative regression, stereotypies and loss of hand use. Epilepsy is present in 50% to 90% with approximately one-third having refractory epilepsy. The ketogenic diet has been used as an antiseizure therapy for more than a century; however, there is limited data on its use in Rett syndrome. In this retrospective single-center case series, we present 9 children with Rett syndrome who were placed on ketogenic diet. There was \u226550% improvement in seizure frequency in 67% (6\/9) and 44% (4\/9) at 6 and 12 months, respectively. Patients with \u226550% seizure reduction had an improvement in cognition and alertness. All 9 had a gastrostomy tube, with 8 starting ketogenic diet with a ketogenic formula and 1 with a food-based diet. The ketogenic diet is well tolerated and has high efficacy for seizures associated with Rett syndrome with two-thirds reporting significant seizure reduction. The presence of a gastrostomy tube can help the initiation and titration of ketogenic diet.<\/jats:p>","DOI":"10.1177\/08830738251329139","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:03:31Z","timestamp":1744279411000},"page":"530-534","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Ketogenic Diet: An Underrecognized Therapy for Rett Syndrome"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4176-9741","authenticated-orcid":false,"given":"Babitha","family":"Haridas","sequence":"first","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Bessone","sequence":"additional","affiliation":[{"name":"Department of Neurology, Johns Hopkins All Children's Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahava","family":"Turner","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5260-5314","authenticated-orcid":false,"given":"Eric","family":"Kossoff","sequence":"additional","affiliation":[{"name":"Johns Hopkins University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12941"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11689-023-09502-z"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.11.001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004515"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12796"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17247"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007316"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-024-07584-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320250525"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/08830738030180011801"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01765.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12225"},{"issue":"1","key":"e_1_3_2_14_2","first-page":"5873208","article-title":"Ketogenic diet decreases emergency room visits and hospitalizations related to epilepsy","volume":"2016","author":"Kayyali HR","year":"2016","unstructured":"Kayyali HR, Luniova A, Abdelmoity A. 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