{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:41:29Z","timestamp":1777804889293,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    Evidence to guide the critical care management of children with ruptured brain arteriovenous malformations is lacking. We aimed to determine whether there are associations between physiologic parameters and outcome in children with ruptured brain arteriovenous malformations. We performed a single-center retrospective review of patients \u226418 years of age with a ruptured brain arteriovenous malformation from 2011 to 2023. Categorization of outcome was based on the Pediatric Stroke Outcome Measure. Descriptive statistics were used. Most patients with an arteriovenous malformation rupture had a poor outcome at discharge (31\/49, 63%) and in follow-up at 3-12 months (21\/37, 57%). Patients who were normothermic and normoglycemic for the first 7 days after arteriovenous malformation rupture were less likely to have a poor outcome at discharge than those who had a temperature \u226538 \u00b0C (odds ratio [OR] 0.14, 95% confidence interval [CI] 0.04-0.52;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.01) or a blood glucose\u2009\u2265200\u2005mg\/dL (OR 0.11, 95% CI 0.01-0.92;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.04). A lower minimum hemoglobin concentration (10.00\u2005g\/dL [standard deviation (SD) 1.67] vs 12.46 g\/dL [SD 6.29],\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    (47) 2.07,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.04) and a higher average partial pressure of carbon dioxide (Pa\n                    <jats:sc>co<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    ) (40.98\u2005mm Hg [SD 4.30] vs 35.58\u2005mm Hg [SD 7.72],\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    (47) \u22122.09,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.046) were also associated with a poor discharge outcome. A higher average maximum temperature was associated with a poor outcome in follow-up (37.46\u00b0 C [SD 0.49] vs 37.09 \u00b0C [SD 0.59],\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    (47) \u22122.09;\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u2009.04). Temperature, blood glucose, hemoglobin concentration, and Pa\n                    <jats:sc>co<\/jats:sc>\n                    <jats:sub>2<\/jats:sub>\n                    are potentially modifiable parameters that could be targeted by quality improvement interventions to improve outcomes in this population.\n                  <\/jats:p>","DOI":"10.1177\/08830738251330110","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:28:09Z","timestamp":1745407689000},"page":"658-668","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Physiologic Parameters with Neurologic Outcome After Arteriovenous Malformation Rupture in Children"],"prefix":"10.1177","volume":"40","author":[{"given":"Julia S.","family":"Keenan","sequence":"first","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Har","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Yan","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics, The George Washington University School of Medicine, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh","family":"Sepeta","sequence":"additional","affiliation":[{"name":"Department of Neuropsychology, Children's National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katelyn","family":"Staso","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Children's National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline R.","family":"Conley","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Children's National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold J.","family":"Sansevere","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-8479","authenticated-orcid":false,"given":"Dana B.","family":"Harrar","sequence":"additional","affiliation":[{"name":"Division of Neurology, Children's National Hospital, Washington, DC, USA"},{"name":"Departments of Neurology and Pediatrics, The George Washington University School of Medicine, Washington, DC, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000183"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cbcd48"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2006.09.017"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12061459"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.568071"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000181746.77149.2b"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/2016.9.PEDS16283"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000407"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1968.28.1.0014"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz404"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.65.4.0476"},{"issue":"2","key":"e_1_3_2_14_2","first-page":"234","article-title":"Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass","volume":"11","author":"Gaies MG","year":"2010","unstructured":"Gaies MG, Gurney JG, Yen AH, et al. Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc. 2010;11(2):234-238. doi:https:\/\/doi.org\/10.1097\/PCC.0b013e3181b806fc","journal-title":"Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.566430"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003448"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/003693305700200504"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.639583"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82544-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000258543.45879.f5"},{"issue":"1","key":"e_1_3_2_22_2","first-page":"239","article-title":"Fever increased in-hospital mortality after subarachnoid hemorrhage","volume":"110","author":"Zhang G","year":"2011","unstructured":"Zhang G, Zhang JH, Qin X. 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