{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:41:29Z","timestamp":1777804889299,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This multicenter study aimed to evaluate the efficacy and safety of oral glycopyrrolate in children with neurodisabilities experiencing moderate-to-severe drooling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 159 children diagnosed with cerebral palsy, epileptic encephalopathy, or autism spectrum disorder were assessed using the Drooling Impact Scale, Drooling Severity and Frequency Scale, and quality of life measures at baseline, week 4, and week 12. A structured dose titration protocol was followed, and adverse events were systematically recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 159 children enrolled, 130 completed the study. Significant improvements were observed in Drooling Impact Scale, Drooling Severity and Frequency Scale, and quality of life scores across all groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Cerebral palsy patients exhibited greater variability in Drooling Impact Scale scores than epileptic encephalopathy and autism spectrum disorder groups at weeks 4 and 12 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.01). Adverse effects were predominantly mild, with constipation being the most common.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Glycopyrrolate is an effective and well-tolerated treatment for drooling in children with neurodisabilities, including autism spectrum disorder and epileptic encephalopathy. It presents a viable pharmacologic option for improving salivary control and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/08830738251330414","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T11:14:21Z","timestamp":1744715661000},"page":"634-640","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Glycopyrrolate for Drooling in Children With Neurodisability: Multicenter Study"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3215-1738","authenticated-orcid":false,"given":"Pinar","family":"Ozbudak","sequence":"first","affiliation":[{"name":"Department of Pediatric Neurology, Ankara Etlik City Hospital, Ankara, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8224-7725","authenticated-orcid":false,"given":"Habibe Koc","family":"Ucar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Adana City Hospital, Adana, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6533-8358","authenticated-orcid":false,"given":"Leman Tekin","family":"Orgun","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Kocaeli University Medical Faculty, Kocaeli, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-2794","authenticated-orcid":false,"given":"Kivilcim","family":"Gucuyener","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Bayind\u0131r Hospital, Ankara, Turkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2007.129478"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2010.03765.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00513"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14350"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-35784-9_2"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.154.12.1214"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1996.02170340046009"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.10.911"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.02.011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-60"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S26893"},{"issue":"2","key":"e_1_3_2_13_2","first-page":"320","article-title":"Sialorrhea and xerostomia in Parkinson's disease patients","volume":"61","author":"\u0160piljak B","year":"2022","unstructured":"\u0160piljak B, Lisak M, Pa\u0161i\u0107 H, Trkanjec Z, Lovren\u010di\u0107 Huzjan A, Ba\u0161i\u0107 Kes V. 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