{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T10:41:46Z","timestamp":1777804906958,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Child Neurol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"\n Fusobacterium nucleatum<\/jats:italic>\n and\n Prevotella loescheii<\/jats:italic>\n are anaerobic gram-negative rods that exist in the oral cavity. To our knowledge, pediatric central nervous system complications with these pathogens have not been well described. An 11-year-old previously healthy vaccinated female child presented for 2 weeks of sinusitis that progressed to left arm and leg hemiplegia. Initial neuroimaging demonstrated a superior sagittal sinus thrombosis and a right hemispheric subdural empyema with midline shift, necessitating surgical evacuation. Culture of the subdural accumulation demonstrated coinfection of\n Fusobacterium nucleatum<\/jats:italic>\n and\n Prevotella loescheii<\/jats:italic>\n . Within 24\u2005hours of evacuation, the patient progressed to have right hemispheric electrographic status epilepticus, with neuroimaging demonstrating reaccumulation of the empyema and a moderate right middle cerebral artery vasospasm. Transcranial doppler ultrasonography of the right middle cerebral artery territory demonstrated mean flow velocities up to 148\u2005cm\/s with a Lindengaard ratio of 3.44. The patient underwent repeat subdural evacuation and was managed with intravenous fluids, permissive hypertension, oral nimodipine, and intravenous milrinone. Electrographic status epilepticus was treated with intravenous lacosamide and levetiracetam. Repeat neuroimaging demonstrated improvement in subdural collection size and resolution of vasospasms. She was discharged after 16 days with continued lacosamide and levetiracetam for seizures, and enoxaparin (Lovenox) for the superior sagittal sinus thrombosis. We present a novel pediatric case of\n Fusobacterium nucleatum<\/jats:italic>\n and\n Prevotella loescheii<\/jats:italic>\n manifesting with rapid subdural empyema reaccumulation after surgical evacuation, status epilepticus, cerebrovascular vasospasms, and cerebral sinus venous thrombosis. Further work is needed to understand the potential neurologic complications of this condition.\n <\/jats:p>","DOI":"10.1177\/08830738251339048","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:02:58Z","timestamp":1747368178000},"page":"563-565","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebrovascular Vasospasms, Cerebral Sinus Venous Thrombosis, and Rapid Empyema Reaccumulation in a Child with a Coinfection of\n Fusobacterium nucleatum<\/i>\n and\n Prevotella loescheii<\/i>"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5823-6107","authenticated-orcid":false,"given":"Rachel","family":"Geiser","sequence":"first","affiliation":[{"name":"University of Arizona College of Medicine\u2013Phoenix"},{"name":"Phoenix Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onilia","family":"Zorio","sequence":"additional","affiliation":[{"name":"Phoenix Children's Hospital"},{"name":"Department of Neurology, Mayo Clinic, Scottsdale, AZ, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5396-2559","authenticated-orcid":false,"given":"Brian","family":"Appavu","sequence":"additional","affiliation":[{"name":"Phoenix Children's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2019.e00616"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03374-5"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2014.11.013"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_95_22"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9030535"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_189_20"}],"container-title":["Journal of Child Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738251339048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/08830738251339048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/08830738251339048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:41:38Z","timestamp":1777495298000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/08830738251339048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,16]]},"references-count":6,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/08830738251339048"],"URL":"https:\/\/doi.org\/10.1177\/08830738251339048","relation":{},"ISSN":["0883-0738","1708-8283"],"issn-type":[{"value":"0883-0738","type":"print"},{"value":"1708-8283","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,16]]}}}